俞远满  副教授  硕士生导师

         Email: ymyu@ecust.edu.cn  

         所属教研室：生物材料研究所

         工作地点：先进材料大楼1005

个人简介

博士毕业于华东理工大学（2020年），随后在刘昌胜院士指导下开展博士后训练并留校任教。入选国家自然科学基金青年基金B类（原优青）、博士后创新人才支持计划及上海市“超级博士后”激励计划等人才计划。研究内容包括促血管化生物材料的构建及其在心梗、脑卒中等重大缺血性疾病中的应用，并阐明生物材料与宿主微环境多细胞相互调控规律与机制。共发表SCI论文48篇，其中以第一作者及通讯作者发表于PNAS、Science Advances、Nature Communications、Biomaterials等期刊20余篇。主持国家重点研发计划子课题、国家自然科学基金面上项目/青年基金项目、中国博士后基金面上项目，参与基金委基础科学中心及国家自然科学基金重点项目。

主要研究方向

仿生促血管化生物材料的构建

材料生物学效应在缺血性疾病中的治疗与应用

免疫微环境与原位再生

衰老调控与再生修复

代表性论文

1. Xinye Chen, Yuanman Yu*, Zirui He, Lina Pan, Jing Wang*, Changsheng Liu*. Machine learning–guided design of cooperative multi-size hydrogel microspheres for osteoarthritis therapy. Biomaterials, 2027, 336:124433.

2. Yeyuan Li^#,  Zirui He^#, Xinye Chen, Lina Pan, Yuanman Yu*,  Changsheng Liu, Bridging the Biotic–Abiotic Divide: Design Principles of Hydrogel Interfaces for Next-Generation Brain-Machine Implants. Advanced Materials Technologies, 2026: e71214. （本科生一作）

3. Yuanman Yu^#, Mingjian Fan^#, Gaoyi Wu, Yongcheng Li, Chao Xia, Wenjiang Ding, Guanglin Li*, Qianjun He*, Wei Tang*, Changsheng Liu*.  Inflamed vessel-anchored release of H₂ across the blood-brain barrier for ischemic stroke neuroprotection. Science Advances, 2026,12:eaea3355.

4. Zirui He,  Xiaoqiao Bai,  Fangru Xie,  Xuan Wang,  Fan Zhang,  Yuanman Yu*,  Yuan Yuan*,  Changsheng Liu*. Co-Treatment With rhBMP-2 and Rapamycin Modulates Osteogenesis–Adipogenesis Balance to Enhance Aged Bone Regeneration. Advanced Science, 2026, 13:e21619.

5.Weili Han^#, Feng Zeng^#, Kaikai Fu^#, Wenjie Lin,  Zheng Cheng, Chang Li, Jun Chen*, Yuanman Yu*, Qiyong Mei*. A dual-targeting nanozyme platform integrating macrophage hitchhiking and tfr transcytosis for precision therapy of ischemic stroke. Nano Today, 2026, 67:102961.

6. Xinye Chen,  Yuanman Yu*,  Zirui He,  Lina Pan,  Jing Wang*,  Changsheng Liu*. Dual-Modular Hydrogel Microparticles with Precision-Modulation of Inflammatory Microenvironment Dictate Full-Thickness Cartilage Regeneration for Osteoarthritis Repair. Advanced Science, 2025, 12:e04965.

7.Yuanman Yu^# *, Rui Chen^#, Xinye Chen, Jing Wang*, Changsheng Liu*. Regulating the bioactivity of non-glycosylated recombinant human bone morphogenetic protein-2 to enhance bone regeneration. Bioactive Materials, 2024, 38, 169-180.

8. Yinli Cao, Yuanman Yu*, Lina Pan, Weili Han, Feng Zeng, Jing Wang*, Qiyong Mei*, Changsheng Liu. Sulfated Polysaccharide-Based Nanocarrier Drives Microenvironment-Mediated Cerebral Neurovascular Remodeling for Ischemic Stroke Treatment. Nano Letters, 2024, 24(17), 5214-5223.

9. Yuanman Yu, Shuang Wang, Xinye Chen, Zehua Gao, Kai Dai, Jing Wang*, Changsheng Liu*. Sulfated oligosaccharide activates endothelial Notch for inducing macrophage-associated arteriogenesis to treat ischemic diseases. PNAS, 2023, 120:e2307480120. (Direct submission).

10. Yuanman Yu, Kai Dai, Zehua Gao, Wei Tang, Tong Shen, Yuan Yuan, Jing Wang*, Changsheng Liu*. Sulfated polysaccharide directs therapeutic angiogenesis via endogenous VEGF secretion of macrophages, Science Advances, 2021, 7(7): eabd8217.

专利

1. 刘昌胜; 戴凯; 王靖; 俞远满; 邓顺书; 朱富威. 一种类骨膜组织的仿生构建方法. CN114246985A.

2. 刘昌胜; 钱江潮; 何亚清; 谢倩; 俞远满; 甘琪; 岳述荣; 魏东升. 一种快速测定骨形态发生蛋白2活性的方法. CN114252410A.