陈芳萍

陈芳萍

                           
姓名
陈芳萍
性别
出生年月
1974年11月
职称
研究员
所属
教研室
教育部医用生物材
料工程研究中心
办公室
地点
实验十五楼
729室
E-mail
联系电话
64251308-710
招生专业
材料科学与工程(材料学)、生物医学工程

 

 
......................................................................................................................................................................................................
主要学习与工作经历
先后获华南理工大学无机非金属材料专业学士、华南理工大学材料学硕士、华东理工大学材料学专业博士。自2001年毕业起一直就职于教育部医用生物材料工程研究中心。2008年在德国耶拿大学(University of Jena)做访问学者,2014年至2015年在加拿大农业部圭尔夫食品研究所高级访问学者。2016年入选上海市浦江人才计划。2021年起担任无机非金属材料专业责任教授。
.......................................................................................................................................................................................................................
主要研究方向:

(1)老龄骨缺损修复材料及其生物学效应研究

(2)功能性微球的开发及其在干细胞治疗、药物递送、医美和组织修复中的应用

(3)基于压电效应生物材料的研制及其在止血、创面愈合、神经修复中的应用

(4)生物质降解材料及其在食品、智慧农业等中的应用

.......................................................................................................................................................................................................................
主要学术兼职
担任中国生物材料学会生物评价分会常务理事、中国仪器仪表学会仪表功能材料学会理事、中国生物材料学会纳米生物材料分会副秘书长、中国生物材料学会生物陶瓷学会委员、上海市硅酸盐学会无机生物与环保专业委员会委员、上海市生物医学工程第七届口腔生物医学工程专业委员会委员等。
.......................................................................................................................................................................................................................
主要学术成果:
科研获奖
作为主要完成人之一获2023年度上海市技术进步奖特等奖、2014年度国家自然科学奖二等奖、2013年度上海市自然科学奖一等奖和2006年上海市科技进步二等奖等国家及省部级奖励。

参编著作

1、实用生物医用材料学, 上海科学技术出版社(2005年出版)ISBN 7-5323-8011-4

2、生物医学工程,华东理工大学出版社(20127月出版)ISBN978-7-5628-3195-2

3、Developments and Applications of Calcium Phosphate Bone Cements》(2017年出版)Springer,ISBN: 978-981-10-5974-2

Chapter 1 Calcium Phosphate Bone Cements: Developments and Applications of Calcium Phosphate Bone Cements第一作者

Chapter 3 Injectable Calcium Phosphate Cements for Hard Tissue Repair, 第一作者

4、纳米生物材料学,第二章,科学出版社(2021年出版)ISBN 703068524-7/TB785


代表性论文(一作或通讯作者)

43、Xinqing Wang, Shuo ChenXiaolei Chen , Juan Wu , Zhenhua Huang ,Fangping Chen* Changsheng Liu *Biomimetic Multi-channel Nerve Conduits with Micro/nanostructures for Rapid Nervous RepairBioactive Materials202441: 577-596

42Zhenhua Huang, Dong Zhang, Laiqiang Tong, Fan Gao,Fangping Chen*, Changsheng Liu, Protonated-chitosan  sponge with procoagulation activity for hemostasis in coagulopathy,Bioactive Materials, 2024(41): 174-192

41、Dong Zhang, Zhenhua Huang, Laiqiang Tong, Fan Gao, Huanxuan Huang, Changsheng Liu, Fangping Chen*, Self-Restoring Cryogels Used for the Repair of Hemorrhagic Bone Defects by Modulating Blood Clots,  

Chemical Engineering Journal, 2024(490): 151421-151435

40Juan Wu, Zhenhua Huang, Dong Zhang, Laiqiang Tong, Fan Gao, Fangping Chen*, Changsheng Liu, Serotonin modified starch-based hemostatic sponges for non-compressible hemorrhage,  International Journal of Biological Macromolecules2024283:137547

39、Laiqiang Tong, Dong Zhang, Zhenhua Huang, Fan Gao, Shaozan Zhang, Fangping Chen*, Changsheng LiuCalcium ion-coupled polyphosphates with different degrees of polymerization for bleeding control, ACS Applied Materials & Interfaces2024, 16, 33, 43244–43256

38、Zhenxi Liu, Dong Zhang, Huili Kang , Xinyi Gu, Fangping Chen*, Changsheng Liu, Robust, self-lubricating and bio-adhesive injectable dECM-loaded hydrogels based on rapid photo-crosslinking for articular cartilage,Applied Materials Today,202441102462

37Shuo Chen, Xinqing Wang, Dong Zhang, Zhenhua Huang, Yina Xie, Fangping Chen*, Changsheng Liu, Tunable piezoelectricity PLLA nanofiber membranes for enhanced  mandibular repair with optimal self-powering stimulation, Regenerative Biomaterials2024https://doi.org/10.1093/rb/rbae150

36、Xiaolei Chen, Dong Zhang, Xinqing Wang, Zhenxi Liu, Huili Kang, Changsheng Liu, Fangping Chen*, Preparation of porous GelMA microcarriers by microfluidic technology for stem-cell culture, Chemical Engineering Journal (IF:16.7) 2023477146444

35、Wenjie Huang, Juan Wu, Zhenhua Huang, Dong Zhang, Fangping Chen*, Changsheng Liu*, A self-gelling starch-based sponge for hemostasis, Journal of Materials Chemistry B, 2023 116):1331-1343

34、Zhenhua Huang, Juan Wu, Yujiao ZhaoDong Zhang, Laiqiang Tong, Fan Gao, Changsheng Liu, Fangping Chen*, Starch-based shape memory sponge for rapid hemostasis in penetrating wound, Journal of Materials Chemistry B, 2023114): 852-864

33、Zhaoyang Niu , Fangping Chen*, He Zhang, Changsheng Liu*, High content of thermoplastic starch , poly(butylenes adipate-co-terephthalate) and Poly(butylene succinate) ternary blends with a good balanced in strength and toughness, Polymers, 2023, 15:2040

32Fangping Chen, Qing Liang, Lijie Mao, Yanrong Yin, Lixin Zhang, Cuidi Li, Changsheng Liu*, Synergy effects of Asperosaponin VI and BMP-2 on osteogenesis and anti-osteoclastogenesis,Bioactive Materials , 2022, 10: 335-344

31、Lijie Mao, Long Bai, Xinqing Huang, Xiaolei Chen, Dong Zhang, Fangping Chen*, Changsheng Liu*,Enhanced Cell Osteogenesis and Osteoimmunology Regulated by Piezoelectric Biomaterials with Controllable Surface potential and charges, ACS Applied Materials & Interfaces, 202214, 39, 44111–44124

30、Xinqing Wang, Zhenhua Huang , Hongyuan Hu, Fangping Chen*, Changsheng Liu*, Glutaraldehyde Crosslinked High Content of Amylose/Polyvinyl Alcohol Blend Films with Potent Tensile Strength and Young’s Modulus, Polymers, 2022,14:5550-5563

29、Lijie Mao, Yanrong Yin, Lixin Zhang, Xiaolei Chen, Xinqing Huang, Fangping Chen*, Changsheng Liu*. Regulation of inflammatory response and osteogenesis to citrate_based biomaterials through incorporation of alkaline fragments,Advanced Healthcare Materials, 2022, 11, 2101590

28、Chengqiang Li, Fangping Chen*, Bowen Lin, Chenhao Zhang, Changsheng LiuHigh content starch/PBAT composites with high-performance by physical-chemical dual compatibilization,  European Polymer Journal2021, 159110737

27Bowen Lin, Chengqiang Li, Fangping Chen*, Changsheng Liu,Continuous Blown Film Preparation of High Starch Content Composite Films with High Ultraviolet Aging Resistance and Excellent Mechanical Properties, Polymers, 2021, 13:3813

26、Chenhao Zhang,Fangping Chen*, Wei Meng, Chengqiang Li, Changsheng LiuContinuous blowing preparation of polyurethane prepolymer modified amylose content starch-PBAT films with high starch content and excellent performance , Carbohydrate Polymers, 2020, 253117168

25、Ruihua Cui, Fangping Chen*, Yujiao ZhaoWenjie Huang, Changsheng Liu, A novel injectable starch-based tissue adhesive for hemostasis, Journal of Materials Chemistry B2020, 8, 8282 - 8293

24Shuda Wei, Fangping Chen*, Ruihua Cui, Yujiao ZhaoChangsheng LiuSelf-assembling RATEA16 Peptide Nanofiber Designed for Rapidly HemostasisJournal of Materials Chemistry B2020, 8, 1897-1905

23Caicai Ge, Fangping Chen*, Lijie Mao, Qing Liang, Yan Su, Changsheng Liu. Strontium ranelate-loaded POFC/β-TCP porous scaffolds for osteoporotic bone repair[J]. RSC Advances. 2020, 10(15): 9016-9025.

22Huantong Su, Shuda Wei,Fangping Chen*, Ruihua Cui, Changsheng Liu, Tranexamic acid-loaded starch hemostatic microspheresRSC Advances, 2019, 9, 6245 - 6253

21Wei Meng, Fangping Chen*, Chenhao Zhang, Ruihua Cui, Peilei Wang, Changsheng LiuPolyurethane prepolymer modified cassava starch based poly(butylene adipate-co-terephthalate) composites with excellent compatibility and high toughnessStarch/Stärke2019doi: [10.1002/star.201900098]

20Junxia Yu, Huantong Su, Shuda Wei,Fangping Chen*, Changsheng Liu*, Calcium contentmediated hemostasis of calcium-modified oxidized microporous starch, Journal of Biomaterials Science Polymer Edition2018, 29(14): 1716-1728

19、Fangping Chen, Xiaoyan Cao, Junxia Yu, Huantong Su, Shuda Wei, Hua Hong, Changsheng Liu*, Quaternary Ammonium Groups Modified Starch Microspheres for Instant Hemorrhage Control, Colloids and Surfaces B: Biointerfaces,2017,159, 937-944

18、Peilei Wang, Fangping Chen*, He Zhang, Wei Meng, Changsheng Liu, Large-scale preparation of jute fiber reinforced starch-based composites with high mechanical strength and optimized biodegradability,Starch/Stärke 2017, 69, 1700052

17、Fangping Chen, Ziyan Song, Li Gao, Hua Hong, Changsheng Liu*,Hierarchically macroporous / mesoporous POC composite scaffolds with IBU-loaded hollow SiO2 microspheres for repairing infected bone defects, Journal of Materials Chemistry B ,2016, 4, 4198 - 4205

16、Fangping Chen, Zhiyan Song, Changsheng Liu* , Reconstruction of femur defect of rabbits using aqueous fast setting and anti-washout injectable calcium phosphate-based cements, Journal of Materials Chemistry B, 2015, 3, 9173 - 9181

15、Fangping Chen, Xiaoyan Cao, Xiaolong Chen, Jie Wei*, Changsheng Liu*, Calcium-modified microporous starch with potent hemostatic efficiency and excellent degradability for hemorrhagecontrol, Journal of Materials Chemistry B, 2015, 3, 4017 - 4026
14、Li Gao , Cuidi Li ,
Fangping Chen*, Changsheng Liu,Fabrication and characterization of toughness-enhanced scaffolds comprising β-TCP/POC using the freeform fabrication system with micro-droplet jetting,Biomed. Mater. 2015,10(3):035009.
13、Cuidi Li, Li Gao,
Fangping Chen*, Changsheng Liu*, Fabrication of mesoporous calcium silicate/calcium phosphate cement scaffolds with high mechanical strength by Freeform Fabrication System with Micro-Droplet Jetting, Journal of Material Science 2015, 50:1-10, DOI: 10.1007/s10853-015-9244-1
12、Qunjie Yin,
 Fangping Chen*, He Zhang, Changsheng Liu, Fabrication and characterization of thermoplastic starch/Poly (butylene succinate) blends with maleated Poly (butylene succinate) as a compatibilizer, Plastics, Rubber and Composites2015,449):362-367

11、Fangping Chen, Yuhao Mao, Changsheng Liu*,Premixed injectable calcium phosphate cement with excellent suspension stability,Journal of Materials Science: Materials in Medicine,2013, 7: 1627-1637

10、Fangping Chen*, Changsheng Liu, Jie Wei, Xiaolong Chen, Physicochemical properties and biocompatibility of white dextrin modified injectable calcium-magnesium phosphate cement, International Journal of Applied Ceramic Technology, 2012, 9(5):979-990

9、Fangping Chen, Changsheng Liu*, Jie Wei,Chen xiao,Gao yanli, Zhao zheng, Preparation and characterization of injectable calcium phosphate cement paste modified by polyethylene glycol-6000, Material Chemical and Physic, 2011,125:818-824
8、
Fangping Chen, Yuhao Mao, Changsheng Liu,Bismuth-doped injectable calcium phosphate cement with improved radiopacity and potent antimicrobial activity for root canal filling, Acta Biomaterialia 2010, 6(8): 3199-3207
7、
Fangping Chen, Yuhao Mao, Changsheng Liu, Miaogen Yu, A novel silicate-doped calcium-based composite dental pulp capping agent, Asia-Pacific Journal of Chemical Engineering,2009, 4 (5) : 522-527
6、
Fangping Chen, Kai Wang, Changsheng Liu*,Crystalline structure and its effect on the degradation of liner calcium polyphosphate bone substitution, Applied Surface Science,2008,255(2):270-272
5、
Fangping Chen, Influence of Xanthan Gum on the Properties of Injectable Calcium Phosphate (ID: 1808) ,P-SAT-C-122,9th World Biomaterials Congress,June 1-5, 2012, Chengdu, China
4、Qunjie Yin,
Fangping Chen*, He Zhang, Changsheng Liu. Mechanical properties and thermal behavior of TPS/PBS blends with maleated PBS as a compatibilizer,Advanced Materials Research, Vol. 1119, .306-309, Jul. 2015
3、Jie Wei,
Fangping Chen, Jung-Woog Shin, Hua Hong, Chenglong Dai, Jiacan Su, Preparation and characterization of bioactive mesoporous wollastonite-polycaprolactone composite scaffold, Biomaterials,2009,30:1080–1088
2、Kai Wang,
Fangping Chen, Changsheng Liu, Christian Rüssel, The effect of polymeric chain-like structure on the degradation and cellular biocompatibility of calcium polyphosphate,Materials Science and Engineering: C,2008,28(8):1572-1578 (SCI/EI)
1
Qunjie Yin, Fangping Chen*, He Zhang, Changsheng Liu. Mechanical properties and thermal behavior of TPS/PBS blends with maleated PBS as a compatibilizerAdvanced Materials Research, 2015. 1119:306-309

 

项目主持情况

11、基于消除衰老细胞和调控骨代谢的复合压电纤维支架用于老年骨质疏松性缺损修复,国家自然科学基金面上项目

10、*************************评估及防护,军工重点项目

9、颌面部硬组织缺损的智能诊疗技术研究与临床应用,十四五重点研发子课题

8、基于续断构筑止血成骨一体化的高粘附可吸收骨蜡,国家自然科学基金面上项目

7、生物全降解淀粉基农用地膜的开发及其应用,上海市科技兴农项目

6、用于战场贯穿伤救治的抗菌性淀粉基快速止血微球,装备预研教育部联合基金

5、模拟低氧应答的高活性钙磷基骨修复材料用于骨质疏松性缺损修复, 国家自然科学基金面上项目

4、适于颌骨大块缺损快速修复的高活性骨修复材料的研发, 国家重点研发计划重点专项

3、表面功能化淀粉基微孔止血材料的构筑及其止血机制探索, 国家自然科学基金面上项目

2、基于生物反应器构建微纳结构的承力镁基活性支架修复大段骨缺损的研究,国家自然科学基金青年项目

1、低碳环保可降解的生物基淀粉塑料合金的研究开发,十二五科技支撑项目