何宏燕

何宏燕



何宏燕,副教授

教育部医用生物材料工程研究中心

材料科学与工程学院


研究方向:生物材料的表界面研究,生物传感及检测,微纳米器械

Emailhyhe@ecust.edu.cn                 Tel021-64251308-709

办公室:徐汇校区实验15729   

邮政地址:上海市梅陇路130112信箱

招生专业:材料科学与工程,高分子材料科学与工程,生物医学工程

                         


 

 
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讲授课程
      聚合物制备工程 (本科课程);高分子生物材料及其应用(本科双语);纳米材料的进展及应用(研究生双语)
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教育背景及工作经历:

1997年毕业于清华大学, 化学工程与工业专业,学士;

2000年毕业于上海大学, 环境科学与工程专业,硕士;

2006年毕业于美国俄亥俄州立大学,化学工程专业,博士


      2006.8-2008.8, 美国俄亥俄州NSF 纳米科学与工程中心, 助理研究工程师;

      2008.9-2013.3, 美国俄亥俄州BioLOC LLC., 资深研究员;

      2013.7-至今,华东理工大学,副教授

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主要学术兼职:

       中国生物材料学会会员;美国化学工程师学会会员;生物医学工程学会会员

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学术成果:
主要承担项目

1.  骨界面高诱骨活性涂层的制备,2023-12,40万元,主持,项目开发,在研。

2. 国家重点研发计划战略性国际科技创新合作重点专项,生物可吸收高分子基纳米活性材料及植入器械制备技术,2024,        694万,课题负责人,在研。

3. 中国科学院-威高研究发展计划攻关项目,【2017】005号,骨诱导型钛合金牙种植体的研制,238万元,主持,在研。

  4. 上海市2018年度“科技创新行动计划”国际学术合作交流项目,兼具抗菌性和骨诱导性涂层的研制及其生物活性调控的研究,2021-0349万元,主持,已结题。

  5. 国家自然科学基金面上项目,新型骨诱导型降解涂层的研制及其生物活性调控的机制研究,2019-1262万元,主持,已结题。

  6. 国家自然科学基金面上项目,基于趋化因子/BMP-2骨再生材料的构建及其协同促进成骨机制,2018-1280万元,参与,已结题。

  7. 上海市自然科学基金项目, 微纳尺度的钛合金表面特性与骨形态发生蛋白微观结构和活性的研究, 2017-09, 10万元,主持,已结题。

  8. 生化检测光盘用于食品检测, 江苏省国际合作项目,2014-12,500万元,参与,已结题。

       9. 微流生物晶片用于免疫蛋白的检测,美国国家科学基金 ,2009-6,50万美金,主持,已结题。


公开及授权专利

        

     - 何宏燕,王丰,金莉莉,彭程. 一种用于原位检测炎症环境的多参数SERS活性微针,CN115399756A20221129

     - 刘昌胜,何宏燕,金莉莉,张钿. Preparation method for Microneedle PatchWO2022142369A1202277

     - 刘昌胜,何宏燕,李春旺,杨梓鹤.一种高诱骨活性牙种植体涂层及其制备方法,CN114366853A2022419

     - 刘昌胜, 何宏燕, 金莉莉, 张钿. 一种微针贴片的制备方法. 专利号:ZL 202011598079.4

     - 刘昌胜, 乔忠乾, 何宏燕. 生物医用活性钛及其合金植入材料的表面改性方法. 专利号:ZL 201710211909.5

     - 余波,李利,何宏燕.一种新型酶联免疫生化光盘监测系统,专利号:ZL201210420985.4

     - 余波,张铁成,叶嘉明,何宏燕,李利.一种糖化血红蛋白免疫检测的微流控芯片,专利号:ZL 201310250236.6


出版书籍及章节


    8章 生物医用陶瓷骨水泥 收编于中文专著《生物医用陶瓷》978-7-03-074544-6, 科学出版社,2023.

             - He HLiu C*Stem cell differentiation mediated by biomaterials/surfaces收编于专著《Polymeric Biomaterials for Tissue Regeneration》,Spring出版,@ 2016 & 2023.

             - Liu C, He H,英文专著Developments and Applications of Calcium Phosphate Bone Cements, Spring出版, 2017.

            - Guan J, He H, Yu B, Lee L J*, Polymeric nanoparticles and nanopore membranes for controlled drug and gene delivery, 收编于专著《Biomed Nanostructures》, Wiley出版,pp115-137, 2008.


代表性论文

      - Peng C, Jin L, Wang F*, Yang H*, He H *. Laser transparent multiplexed SERS microneedles for in situ and real-time detection of inflammation. Biosensors and Bioelectronics 225:115079, 2023.

      - Sha D, Tang S, Dong Z, Chen K, Wang N, Liu C, Ling X*, He H*, Yuan Y*. Wearable, antibacterial, and self-healable modular sensors for monitoring joints movement ultra-sensitively. European Polym J 180:111617, 2022.

      - Liu Y, Wang J, Jiang M, Li Y, Zhang Q*He H.* Osteoindu,ctive hybrid hydrogel membranes for in situ bone regeneration in hyperglycemia, Colloids and Surfaces B: Biointerfaces 214:112450, 2022.

      - Li Y, Guo X, Dong S, Zhu T, Chen Y, Zhao S, Xie G, Jiang J*, He H*, Liu C, Zhao J*. A triple-coated ligament graft to facilitate ligament-bone healing by inhibiting fibrogenesis and promoting osteogenesis. Acta Biomaterialia, 115:160-175, 2020.

      - Li Y, Wu J, He H*, Liu C*, Zhao J.* Chondroitin sulfate-immobilized polyethylene terephthalate with ECM-mimetic immunoregulatory function for achieving in vivo osseointegration. J. Mater. Chem. B, 7:7756-7770, 2019.

      - 何宏燕,郜彭阳,乔忠乾,屈雪,刘昌胜*。钛金属表面微纳结构协同抗菌肽的抗菌性能研究,中国修复重建外科杂志,2018.

      - Qin J, He H*, Zhang W, Chen F, Liu C*.Effective incorporation of rhBMP-2 on implantable titanium disks with microstructures by using electrostatic spraying deposition. RSC Advances, 6: 51914-51923, 2016.

      - Yang Y, Zhao X, Wang L, Wang F*, He H*, Wang X. Photo-polymerization of monomer crystals producing thermo-responsive micropatterns to direct cell growth and cell selective harvestPolym. 74(1):150-158, 2015.

      - Zhang W, He H, Tian Y, Gan Q, Zhang J, Yuan Y*, Liu C*. Calcium ion-induced formation of β-sheet/-turn structure leading to alteration of osteogenic activity of bone morphogenetic protein-2. Scientific Report 5:12694-12700, 2015.

      - He H, Luedke E, et al., A naonoporous cell-therapy device with controllable biodegradation for long-term drug release. J Control Rel. 165(3): 226-233, 2013.

      - Wang F, He H(co-first), etc.  Micropatterned thermoresponsive surfaces by polymerization of monomer crystals: modulating cellular morphology and cell substrate interactions. Analy Chem. 84(21): 9439- 9445, 2012.

      - He H, Grignol V, et al.  Use of a Nanoporous Biodegradable Miniature Device to Regulate Cytokine Release for Cancer Treatment, J Control Rel. 151, 239-245, 2011.

      - He H, Yuan Y, Wang W, Chiou N-R, Epstein A J, and Lee L J, Design and testing of a CD-like biochip for enzyme-linked immunosorbent assay. Biomicrofluidics 3, 1-17, 2009.

      - Yuan Y, He H, and Lee L J, Protein A-based antibody immobilization onto polymeric microdevices for enhanced sensitivity of enzyme-linked immunosorbent assay. Biotech Bioeng. 102, 891-901, 2009.

      - Yen C, He H, Lee L J, and W. Ho, Synthesis and characterization of polycaprolactone nanoporous membranes for biomedical applications. J Mem Sci.343, 180-188, 2009.

      - Zhang X, He H(co-first author), Yen C, Ho W, and Lee L J, A biodegradable, immunoprotective, dual nanoporous capsule for cell based therapies. Biomaterials 29, 4253-4259, 2008.

      - Guan J, He H, Lee L Jand Hansford D J, Fabrication of particulate reservoir-containing, capsule-like, and self-foldable polymer microstructures for drug delivery. Small 3, 412-418, 2007.

      - He H, Li L,and Lee L J, Photopolymerization and structure formation of methacrylic acid based hydrogels in water/ethanol mixture. Polym. 47, 1612-1619, 2006.

      -  He H, Guan J, and Lee L J, Oral delivery devices based on self-folding hydrogels. J Control Rel.110(2), 339-346, 2006.

      - Guan J, He H, Hansford D J, and Lee L J, Self-folding hydrogel three-dimensional microstructures.J Phy Chem B. 109(49), 23134-23137, 2005.

      - He H, Cao X, and Lee L J, Design of a novel hydrogel-based intelligent system for controlled drug release. J Control Rel.95, 391-402, 2004.