研究生信息
王靖

 

姓名
王靖
性别
女
出生年月
1972.5
职称
研究员
所属
教研室
生物材料
办公室
地点
实验十五楼729室
E-mail
wangjing08@ecust.edu.cn
联系电话
13661772722
招生专业
材料科学与工程，生物医学工程
 
 
主要经历与简历：
1999-2002 华东理工大学 材料学专业 硕士
2003-2007华东理工大学 材料学专业 博士
2007-至今 留校任教

2012年 入选教育部新世纪优秀人才计划

2016.1-2016.8 澳大利亚昆士兰科技大学 高级访问学者 

主要研究方向：

（1）活性生物材料的构建及材料的生物学效应；

（2）骨修复材料及骨组织原位再生；

（3）抗衰老生物材料及退行性疾病治疗新技术；

（4）干细胞与再生医学

 
主要社会兼职：
  中国生物材料学会会员；国际华人骨研学会终身会员
 
 
 


主
要
学
术
成
果
发表论文、专著、专利、获奖情况
 Kai Dai, Qinghao Zhang, Tong Shen, Yuanman Yu, Shunshu Deng, Shuang Zhang, Yuanzhong Pan, Fuwei Zhu, Jing Wang*, Changsheng Liu*, A BMP-2-triggered in vivo osteo-organoid for cell therapy. Science Advances, 2023, 9: eadd1541
Yuanman Yu, Kai Dai, Zehua Gao, Wei Tang, Tong Shen, Yuan Yuan, Jing Wang*, Changsheng Liu*, Sulfated polysaccharide directs therapeutic angiogenesis via endogenous VEGF secretion of macrophages. Science Advances, 2021, 7: eabd8217
Kai Dai, Shunshu Deng, Yuanman Yu, Fuwei Zhu, Jing Wang*, Changsheng Liu*, Construction of developmentally inspired periosteum-like tissue for bone regeneration. Bone Research, 2022,10: 1

Kai Dai, Tong Shen, Yuanman Yu, Shunshu Deng, Lijie Mao, Jing Wang*, Changsheng Liu*. Generation of rhBMP-2-induced juvenile ossicles in aged mice. Biomaterials, 2020, 258: 120284

Kai Dai, Wenchao Zhang, Shunshu Deng, Jing Wang*, Changsheng Liu*, Sulfated polysaccharide regulates the homing of HSPCs in a BMP-2-triggered in vivo osteo-organoid. Advanced Sciences, 2023: 2301592

Long Bai, Yanpeng Liu, Xiaohui Zhang, Peiru Chen, Ruiqiang Hang, Yin Xiao*, Jing Wang*,Changsheng Liu*, Osteoporosis remission via an anti-inflammaging effect by icariin activated autophagy. Biomaterials, 297: 122125

Xiaoying Zhang, Dandan Cao, Liting Xu, Yanhua Xu, Zehua Gao, Yuanzhong Pan, Ming Jiang, Yuhui Wei, Lihua Wang, Yue Liao, Qigang Wang, Lei Yang, Xiaocui Xu, Yawei Gao, Shaorong Gao, Jing Wang, Rui Yue 1Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation. Cell Stem Cell, 2023, 30(4): 378-395

Xiaogang Wang, Luli Ji, Jing Wang*, Changsheng Liu*, Matrix stiffness regulates osteoclast fate through integrin-dependent mechanotransduction. Bioactive Materials,2023, 27: 138-153

Qinghao Zhang*, Yuanda Liu, Jie Li, Jing Wang*, Changsheng Liu*, Recapitulation f growth factor-enriched microenvironment via BMP receptor activating hydrogel. Bioactive Materials, 2023, 20: 638-650
Xiaogang Wang, Yuanman Yu, Luli Ji, Zhen Geng*, Jing Wang*, Changsheng Liu*, Calcium phosphate-based materials regulate osteoclast-mediated osseointegration. Bioactive Materials, 2021, 6: 4517-4530
Rui Chen, Jing Wang*,Changsheng Liu*, Biomaterials Act as Enhancer for Growth Factors in BoneRegeneration. Advanced Functional Materials, 2016, 26: 8810-8823
ZhenGeng, XiaogangWang, YuanmanYu, LuliJi,JingWang*, ChangshengLiu*,  Attenuating osteoarthritis by a high efficient anti-bone resorption injectable pH-responsive bisphosphonate-conjugated nano-apatite system. Chemical Engineering Journal, 2020, 127674
Zhen Geng, Luli Ji, Zhaoyang Li *, Jing Wang*, Hongyan He, Zhenduo Cui, Xianjin Yang, Changsheng Liu. Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis. Bioactive Materials, 2021, 6 (4), 905-915
Zhen Geng, Zhaoyang Li, Zhenduo Cui, Jing Wang*, Xianjin Yang, Changsheng Liu*. A novel bionic topography with miR-21 coating for improving bone-implant integration through regulating cell adhesion and angiogenesis. Nano Letters, 2020, 20 (10), 7716-7721
Tong Shen, Kai Dai, Yuanman Yu, Jing Wang*, Changsheng Liu*. Sulfated Chitosan Rescues Dysfunctional Macrophages and Accelerates Wound Healing in Diabetic Mice. Acta Biomaterialia, 2020, 117: 192-203
Yang Liu, Lingyan Cao, Shuang Zhang, Luli Ji, Jing Wang*, Changsheng Liu*. Effect of hierarchical porous scaffold on osteoimmunomodulation and bone formation. Applied Materials Today, 2020, 20: 100779
Yuanman Yu#, Rui Chen#, Yuan Yuan, Jing Wang*, Changsheng Liu*, Affinity-selected polysaccharide for rhBMP-2-induced osteogenesis via BMP receptor activation.Applied Materials Today 2020, 20: 100681
Zhen Geng, Yuanman Yua, Zhaoyang Li* Lili Ma, Shengli Zhu, Yanqin Liang, Zhenduo Cui*, Jing Wang*, Xianjin Yang Changsheng Liu, miR-21 promotes osseointegration and mineralization through enhancing both osteogenic and osteoclastic expression. Materials Science & Engineering C 2020, 111: 110785
Yang Liu, Shengbing Yang, Lingyan Cao, Xiaohui Zhang, Jing Wang*, Changsheng Liu*, Facilitated vascularization and enhanced bone regeneration by manipulation hierarchical pore structure of scaffolds.Materials Science & Engineering C, 2020, 110: 110622
Lingyan Cao, Jing Wang*, Juan Hou, Wanli Xing, Changsheng Liu*, Vascularization and bone regeneration in a critical sized defect using 2-N,6-O-sulfated chitosan nanoparticles incorporating BMP-2. Biomaterials, 2014, 35:684-698
Fan Yang, Jing Wang*, Juan Hou, Han Guo, Changsheng Liu*, Bone regeneration using cell-mediated responsive degradable PEG-based scaffolds incorporating with rhBMP-2, Biomaterials, 2013, 34:1514-1528

Yuanman Yu, Jie Chen, Rui Chen, Lingyan Cao, Wei Tang, Dan Lin, Jing Wang*, Changsheng Liu*, Enhancement of VEGF-mediated angiogenesis by 2-N,-6-O-sulfated chitosan-coated hierarchical PLGA scaffolds, ACS Applied Materials & Interfaces, 2015, 7: 9982-9990

Yuanman Yu, Rui  Chen, Yi Sun, Yuanzhong Pan, Wei Tang, Shuang Zhang, Lingyan Cao, Yuan Yuan, Jing Wang*, Changsheng Liu, Manipulation of VEGF-induced angiogenesis by 2-N, 6-O-sulfated chitosan, Acta Biomaterialia, 2018, 71: 510-521

Rui Chen, Yuanman Yu, Wenjing Zhang, Yuanzhong Pan, Jing Wang*, Yin Xiao*, Changsheng Liu*, Tuning the Bioactivity of Bone Morphogenetic Protein-2 with Surface Immobilization Strategies. Acta Biomaterialia, 2018, 80: 108-120 




 
 
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来源
基于材料生物学效应的骨组织原位再生机制研究国家自然科学基金重点项目
生物可吸收高分子基纳米活性材料及植入器械制备技术
国际重点研发计划战略性国际合作重点专项
调控骨髓微环境的活性生物材料构建及其促进造血发生的机制研究
国家自然科学基金面上项目
激发巨噬细胞免疫应答的骨修复材料构建及其促进骨组织再生的机制研究国家自然科学基金面上项目
磺化类肝素促进成骨过程血管化的机制研究
国家自然科学基金面上项目
生物响应型降解材料及其对骨组织再生的调控研究
国家自然科学基金项目
多级微纳结构生物活性材料促进骨组织快速修复的研究

国家重大科学研究计划

具可塑性的有机/无机复合促进成骨制品的研制
上海市“科技创新行动计划”
新一代骨植入材料关键技术与产品研发“十二五”国家科技支撑计划
微创可注射活性骨修复产品的研制中国科学院-威高研究发展计划攻关项目