李玉林
发布时间:2020-09-29   访问次数:3690   作者:

姓名

性别

职称

所属教研室

李玉林

副教授

教育部医用生物材料工程研究中心

E-mail

yulinli@ecust.edu.cn

办公室

实验十五楼-724

主要研究方向:

结合化学、材料学和生物学技术,致力于智能纳米微球的药物控释、高强度硬组织修复生物材料的应用研究,包括具有靶向功能的抗肿瘤缓释材料、可降解生物活性材料、活性陶瓷材料的高性能化等。

人才培养与国际交流:

担任高材161和材料2002班班导师,指导2USRP4项大学生创新项目。分别指导大学生获得第一届上海市大学生生命科学竞赛三等奖、第十三届“华陆科技·奋进杯”大学生课外学术科技作品竞赛二等奖等。2014年以来指导研究生18名,其中3名硕士研究生(许欣、罗炜、郑玲)获得国家奖学金、1名博士研究生(王宜峰)获校优秀学生称号、1名硕士研究生(郑玲)获得校优秀毕业生称号,5名硕士研究生(王雅琪、郑玲、罗炜、陈璨、许梦瑶)获校一等奖学金。分别指导研究生获得第三届国际纳米药物大会JACS最佳墙报奖(郑玲)、中国生物材料大会产业化论坛创新创业大赛三等奖(罗炜)。积极参与包括“111”引智计划在内的国际学术交流活动,注重具有国际视野的材料领域年轻人才培养,指导2名学生(刘天舒、陈占立)获得国家奖学金赴澳留学。


主要经历与简历:

1995/9 - 1999/6  湖北大学,化学与材料科学学院,学士

1999/9 - 2002/6  湖北大学,化学与材料科学学院,硕士

2002/9 - 2005/7  中国科学院,化学研究所 ,博士

2005/9 - 2006/7  法国里尔科技大学,固态结构与性能实验室,访问学者

2006/8 - 2008/3  日本国立物质材料研究所,生物材料中心,博士后

2008/5 - 2009/7  日本九州大学,应用化学系,Global-COE博士后

2009/7 - 2014/5  葡萄牙马德拉大学,化学与物质研究中心,研究助理教授

2014/6 –  至今  华东理工大学,材料科学与工程学院,副教授


承担/参与项目名称(角色/资助金额/资助期限/课题来源)

1. 兼具干细胞募集能力和成骨诱导功能的微纳结构活性材料的构建及快速成骨机制研究(主持 / 60.0万元 / 2018-2021/国家自然科学基面上项目

2. 兼具成血管能力的水凝胶联合基因工程化内源性脂肪干细胞治疗脊髓损伤研究(主持 / 40.0万元 / 2018-2021/上海市科委港澳台科技合作项目

3. 高品质聚乳酸纤维及其纺织品规模化制备与应用(子课题负责人/ 80.0万元 / 2017-2021/国家重点研发计划

4. 生物可吸收高分子基纳米活性材料及植入器械制备技术(课题负责人 / 274.0万元 / 2019-2023/ /国家重点研发计划

5. 非细胞型活性仿生支架促进老年骨损伤修复应用研究主持 / 62.0万元 / 2020-2023/国家自然科学基面上项目

6. 基于微纳结构的高弹高强复合活性骨修复材料的研究 (主持 / 10.0万元 / 2015-2017/上海市国际科技合作基金

7. 强度可控的多级微纳结构活性支架材料与生长因子协同骨修复研究 (主持 / 30.0万元 / 2015-2017/上海市国际科技合作基金

8. 基于3D打印技术构建高强度活性支架材料与生长因子协同骨修复研究(主持 / 10.0万元 / 2015-2017/上海市人才发展基金

9. 仿生骨多级结构活性支架材料的构建及促进骨组织快速修复的研究(主持 / 16.0万元 / 2017-2018/教育部基本科研业务费

10. Self-assembled Nanoparticles based on PEG-PLA-dendrimer building blocks for dual gene/drug delivery(主持 / 15.7万欧 / 2012-2015/葡萄牙科技部纳米专项

近期代表性论文

1.        Fei Yu, Ruixian Lian, Lu Liu, Ting Liu, Chao Bi, Kan Hong, Shuiquan Zhang, Jiazi Ren, Haikun Wang, Ningjuan Ouyang, Lin-Juan Du, Yuan Liu, Lujun Zhou, Yan Liu, Bing Fang, Yulin Li*, Sheng-Zhong Duan*, Lunguo Xia*. Biomimetic hydroxyapatite nanorods promote bone regeneration via accelerating osteogenesis of BMSCs through T cell-derived IL-22, ACS Nano,https://doi.org/10.1021/acsnano.1c08281. (IF: 15.9)

2.         Fangxue Zhang, Peng Liu, Wang Ding, Qingbing Meng, Dihan Su, Qichen Zhang, Ruixian Lian, Baoqing Yu, Mingdong Zhao, Jian Dong, Yulin Li*, Li-Bo Jiang. Injectable MusselInspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration. Biomaterials, 2021, 278, 121169. (IF:12.479)

3.         Kaikai Zheng, Yu Tong, Shihao Zhang, Ruiying He, Lan Xiao, Zoya Iqbal, Yuhong Zhang, Lei Zhang, Libo Jiang, and Yulin Li*. Flexible Bicolorimetric Polyacrylamide/Chitosan Hydrogels for Smart RealTime Monitoring and Promotion of Wound Healing. Adv. Funct Mater. 2021, DOI:10.1002/adfm.202102599. (IF: 16.836)

4.         Wei Hu, Tingting Xiao, Du Li, Yu Fan, Lingxi Xing, Xipeng Wang, Yulin Li*, Xiangyang Shi, Mingwu Shen. Intelligent Molybdenum Disulfide Complexes as a Platform for Cooperative Imaging-Guided Tri-mode Chemo-Photothermo-Immunotherapy. Adv. Sci., 2021, DOI: 10.1002/advs.202100165. (IF: 15.8)

5.         Shihao Zhang, Yamin Li, Xiaofeng Qiu, Anqi Jiao, Wei Luo, Xiajie Lin, Xiaohui Zhang, Zeren Zhang, Jiachan Hong, Peihao Cai, Yuhong Zhang, Yan Wu, Jie Gao, Changsheng Liu, Yulin Li*. Incorporating redox-sensitive nanogels into bioabsorbable nanofibrous membrane to acquire ROS-balance capacity for skin regeneration. Bioact Mater., 2021, 6, 3461-3472. (IF: 14.593)

6.         Libo Jiang, Shenglong Ding, Wang Ding, Dihan Su, Fangxue Zhang, Taiwei Zhang, Xiaofan Yin, Lan Xiao, Yulin Li*, Fenglai Yuan, Jian Dong. Injectable Sericin Based Nanocomposite Hydrogel for Multi-modal Imaging-guided Immunomodulatory Bone Regeneration. Chem. Eng. J., 2021, 418, 129323. (IF13.273)

7.         Yulin Li Ling Zheng Lan Xiao Liudi Wang Jingyuan Cui Dongyong Sha Changsheng Liu.Eco-friendly development of an ultrasmall IONP-loaded nanoplatform for bimodal imaging-guided cancer theranostics. Biomaterials Science, 2020, 8(22), 6375-6386. (IF: 6.183)

8.         Xiajie Lin, Yamin Li, Wei Luo, Lan Xiao, Zeren Zhang, Jinzhong Zhao*, Changsheng Liu* and Yulin Li*. Leucine-activated nanohybrid biofilm for skin regeneration via improving cell affinity and neovascularization capacity. Journal of Materials Chemistry B, 2020,8, 7966-7976. (IF: 5.344, 精选论文)

9.         Dong Zhou,Sainan Liu,Yongjun Hu,Shiwei Yang,Bing Zhao,Kaikai Zheng,Yuhong Zhang,Peixin He, Guoyan Mo*,,and Yulin Li*,.Tumor-mediated shape-transformable nanogels with pH/redox/enzymatic-sensitivity for anticancer therapy. Journal of Materials Chemistry B, 2020, 8(17): 3801-3813. (IF: 5.344, 热点论文)

10.     Jianming Wu, Xi Cheng, YulinLi, Guisheng Yang. Constructing biodegradable nanochitin-contained chitosan hydrogel beads for fast and efficient removal of Cu(II) from aqueous solution. Carbohydrate Polymers, 2019, 211, 152-160. (IF: 7.182)

11.     Mingji Su, Yong Liu, Shihong Li, Zhengping Fang, Benqiao He, Yuhong Zhang, Yulin Li, Peixin He. A rubber-like, underwater superoleophobic hydrogel for efficient oil/water separation. Chemical Engineering Journal, 2019, 361, 364-372. (IF13.273) 

12.     Jiahui Du, Peng Xie, Shuxian Lin, Yuqiong Wu, Deliang Zeng, Yulin Li*, Xinquan Jiang*. Time-Phase Sequential Utilization of Adipose-Derived Mesenchymal Stem Cells on Mesoporous Bioactive Glass for Restoration of Critical Size Bone Defects. ACS Appl. Mater. Interfaces, 2018, 10 (34), 28340–28350. (IF: 9.229)

13.     Ping Ji, Bingjie Zhou, Yuan Zhan, Yifeng Wang, Yuhong Zhang, Yulin Li, and Peixin He. Multi-stimulative nanogels with enhanced thermosensitivity for intracellular therapeutic delivery. ACS Appl. Mater. Interfaces. 2017, 9 (45), 39143–39151. (IF: 8.758)

14.     Yulin Li and Changsheng Liu*. Nanomaterials-based Bone Regeneration. Nanoscale, 2017, 9(15), 4862-4874. (IF:6.895)

15.     Panpan Yi, Yifeng Wang,Shihao Zhang, Yuan Zhan,Yuhong Zhang, Zhengguang Sun, Yulin Li,*and Peixin He. Stimulative Nanogels with Enhanced Thermosensitivity for Therapeutic Delivery via β-Cyclodextrin-induced Formation of Inclusion Complexes. Carbohydrate Polymers, 2017, 166, 219-227. (IF: 7.182).

16.     Yulin Li, Yin Xiao, Changsheng Liu*. The Horizon of Materiobiology: A Perspective on Material-Guided Cell Behaviors and Tissue Engineering. Chemical Reviews, 2017,117(5), 4376−4421. (IF:60.622)

17.     Yifeng Wang;Yi Sun; Jine Wang;Yang Yang; Yulin Li*; Yuan Yuan; Changsheng Liu*. Charge-Reversal APTES-modified Mesoporous Silica Nanoparticles with High Drug Loading and Release Controllability. ACS Appl Mater Interfaces, 2016, 8(27), 17166-17175.(IF: 9.229)

18.     Guoying Wang, Yaying Chen, Peng Wang, Yifeng Wang, Hua Hong, Yulin Li, Jiangchao Qian, Yuan Yuan, Bo Yu, Changsheng Liu*. Preferential Tumor Accumulation and Desirable Interstitial Penetration of Poly(lactic-co-glycolic acid) Nanoparticles with Dual Coating of Chitosan Oligosaccharide and Polyethylene glycol-poly(D,L-lactic acid). Acta Biomaterialia, 2016, 29(1), 248–260. (IF:7.242)

19.     Yulin Li*, Dina Maciel, João Rodrigues, Xiangyang Shi, Helena Tomás. Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery. Chemical Reviews, 2015, 115(16), 8564-8608.(IF:60.622)

20.     Guoying Wang, Dina Maciel, Yilun Wu, João Rodrigues, Xiangyang Shi, Yuan Yuan, Changsheng Liu, Helena Tomás, Yulin Li*. Amphiphilic Polymer-Mediated Formation of Laponite®-Based Nanohybrids with Robust Stability and pH Sensitivity for Anticancer Drug Delivery, ACS Appl. Mater. Inter., 2014, 6(19), 16687–16695. (IF: 9.229)

21.     Mara Gonçalves, Dina Maciel, Débora Capêlo,Shili Xiao, Wenjie Sun, João Rodrigues, Xiangyang Shi, Helena Tomás, Yulin Li*. Dendrimer-Assisted Formation of Fluorescent Nanogels for Drug Delivery and Intracellular Imaging, Biomacromolecules, 2014,15(2), 492–499. (IF: 6.092)

22.     Mara Gonçalves, Priscilla Figueira, Dina Maciel, João Rodrigues, Xue Qu, Changsheng Liu, Helena Tomás, Yulin Li*. pH-sensitive Laponite®/doxorubicin/alginate Nanohybrids with Improved Anticancer Efficacy, Acta Biomaterialia, 2014, 10(1), 300-307. (IF: 7.242)

23.     Dina Maciel, Priscilla Figueira, Shili Xiao, Xiangyang Shi, Helena Tomás, Yulin Li*. Redox-responsive Alginate Nanogels with Enhanced Anticancer Cytotoxicity. Biomacromolecules, 2013, 14(9), 3140–3146. (IF: 6.092)

24. Yulin Li*, João Rodrigues and Helena Tomás. Injectable and Biodegradable Hydrogels: Gelation, Biodegradation and Biomedical Applications, Chem. Soc. Rev., 2012, 41(6), 2193-2221. (IF:54.564)