刘润辉    教授、博导、获国家杰出青年科学基金

                上海市青年学术带头人、东方学者、霍尼韦尔学者

研究方向（多领域交叉研究）：模拟多肽的高分子生物材料、生物医药、高端医疗器械、生物传感领域交叉研究 

方向1：高分子合成、水凝胶、高分子生物材料、骨软骨血管等组织修复、抗菌材料、干细胞培养载体、干细胞体内治疗

方向2：多肽药物发现、抗耐药细菌和真菌多肽、抗肿瘤药物发现和修饰、糖尿病药物发现和修饰、糖尿病药物长效释放、药物及mRNA递送

方向3：智能传感（集成电路材料）、脑机接口、生物检测芯片、人工智能（用于生物材料和生物医药的设计和发现）、计算模拟

Email： rliu@ecust.edu.cn       Tel: 021-64253402

办公室：徐汇校区科辅二楼二层C203   

邮政地址：上海市梅陇路130号546信箱

招生专业：材料科学与工程

本课题组常年招收博士后；招收博士、硕士研究生 （从未有硕士延期，希望有生之年无任何硕士延期毕业）

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教育及研究经历：

2004-2009 美国 普渡大学(Purdue University) 博士

2009-2010 美国 加州理工学院(California Institute of Technology) 博士后

2010-2014 美国 威斯康星大学麦迪逊校区(University of Wisconsin-Madison) 博士后

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学生培养：

学生获奖：

有5人入选博士后最高荣誉人才项目，国家“博新计划”

1人入选国家资助博士后研究人员计划B档

3人入选上海市“超级博士后”激励计划

1人获得上海市青年五四奖章（当年度唯一学生获得者）

1人获得京博科技奖-化学化工与材料京博优秀博士奖铜奖 (全国10人获得 )，

3人入选张江树优博培育计划

2人入选华东理工大学“大学生年度人物”

1人获得华东理工大学十大学术进展荣誉称号

1人获得华东理工大学“榜样力量代言人”荣誉称号

10人获得华东理工大学优秀学生荣誉称号。

学生获奖学金：

3人获得国家奖学金

1人获成思危奖学金

40人次获得赢创奖学金、华昌奖学金等各类奖学金

20人获得华东理工大学学业奖学金一等，10人获得华东理工大学学业奖学金二等。

学生国际交流：

所指导学生中，有5人成功申请到海外知名高校（如约翰霍普金斯、杜克大学）继续深造。

学生参加学术交流和竞赛：

研究生获得第九届先进纤维与聚合物材料国际会议（ICAFPM）杰出墙报奖、优秀墙报奖，

第十一届先进纤维与聚合物材料国际会议（ICAFPM）优秀报告奖（2人次）

ACS年会优秀报告奖（4人次）

2023 TERMIS-AP WEBINAR STUDENT PRESENTATION CONTEST（金奖）

英国皇家化学会-清华大学新星学术论坛口头报告三等奖

上海市百万青少年争创“明日科技之星“二等奖

生物反应器工程国家重点实验室青年论坛优秀口头报告奖

浙江大学“组织再生关键科技”博士生夏令营最佳报告奖（2人次）

华东理工大学研究生学术论坛（第二十三届“特等奖“、第二十四届”一等奖“、第二十五届”二等奖“、第二十八届”特等奖“）

指导学生参加第四届全国高分子材料创新创业大赛并获得铜奖。

代表性学术论文:

52.   Liu L., Zhou M., Xiao X., Cong Z., Wu Y., Xie J., Zhang Q., Zhang J., Jiang W., Liu, R.*,  Combinatorial synergistic antifungal therapy using a host defense peptide mimic that self-assembles into delivery micelles. Nat Biotechnol. 2026. (DOI: https://doi.org/10.1038/s41587-025-02930-3)

51.   Xiao, X., Wu, Y., Zhou, M., Xiao X., Cong Z., Wang J., Wu Z., Sun T., Zhang J., Liu L., You C., Zhang H., Chen K., Xie J., Zou, J, Liu, R.*,  Nature Microbiology, in revision

50.   Xie, J.^#.; Zhou, M.^#.; Cong, Z.; Xiao, X.; Liu, L.; Chen, S.; Jiang, W.; Wu, Y.; Liu, R.*, A host defense peptide-mimicking prodrug activated by drug-resistant Gram-negative bacterial infections. Sci. Transl. Med. 2025, 17(801), eadl4870. (Cover, Highlighted by Nat. Rev. Drug Discov., Highlighted by Cell Host & Microbe)

49. Wu, Y.*; Chen, K.; Wang, J.; Dai, W.; Yu, H.; Xie, X.; Chen, M.; Liu, R.*, Open-vessel Polymerization of N-carboxyanhydride (NCA) for Polypeptide Synthesis Nat. Protocol, 2024, DOI:10.1038/s41596-024-01062-3.

48.  Zhou, M.#;Liu, L.#; Cong, Z.; Jang, W.; Xiao X.; Xie J.; Luo, Z.; Chen, S.; Wu, Y.; Xue, X.; Shao, N.; Liu, R.* Membrane and DNA Dual-Targeting Strategy to Combat Multidrug-Resistant Fungi and Mitigate Antifungal Resistance, Nature Microbiology, 2024, 9,1325-1339.  (Highlighted by BioCentury Innovations)

47.  Jiang, W.; Zhou, M.; Chen, K.; Xiao, X.; Shi, J,; Zhang, H.; Xie, J.; Chen, S.; Chen, M.; Cong, Z.; Liu, L.; Wu, Y.*; Liu, R*, Biguanide-Functionalized Peptide Mimics Effectively Combat Drug-Resistant ESKAPE Pathogens and Meningitis. Nat. Commun. 2026, 17 (1), 336

46.  Chen, K.^#; Wu, Y.^#, *; Chen, M.; Huang, X.; Zou, J.; Chen, X.; Liu, R.*, Cationic-catalyst strategy enabling ultrafast and controlled polymerization and efficient depolymerization towards a circular polymer economy. Angew. Chem. Int. Ed. 2025, 17 (1), 336 (DOI: 10.1002/anie.202520392.) (VIP paper) 

45.  Zhang, H.; Liang, Q.; Jiang, W.; Chen, Q.; Chen, K.; Cong, Z.; Liu, G.; Shi, J.; Ji, Y.; Li, W.; Dou, M.; Wang, Y.; Liu, L.; Chen, L.; Zhang, D.; Wu, Y.; Liu, R.*., Poly(bis(guanidinium)-oxazoline)–Insulin Complex Exerting Long-Acting Glucose-Responsive Insulin Release in Mice and Minipigs. J. Am. Chem. Soc. 2025,147, 40576−40589 

44. Chen, K.; Wu, Y.*; Chen, M.; Wang, J.; Zhou, M.; Chen, X.; Liu, R.*  Single-Center Trifunctional Organocatalyst Enables Fast and Controlled Polymerization on N-Carboxyanhydride. ACS Cent. Sci. 2025, 11(3), 382–392. (Front Cover, Highlighted by ACS Cent. Sci. as a First Reaction (DOI:10.1021/acscentsci.4c01926))

43.  Chen, Q.; Gu, J.; Zhang, H.; Zhang, D.; Wang, Y.; Liu, G.; Zhu, X.; Zhang, X.; Cao, C.; Yuan, Y.; Liu, R.* Promoting implant osseointegration via the osteoblast-selective β-amino acid polymer strategy. Nat. Commun, 2025, 16 (1), 7190.

42.  Zhang, J.; Xiao, X.; Zhang, D.; Liu, L.; Zhang, W.; Liang, Q.; Liu, R.* The Cheap Silk Sericin Displaying Chaperone-Like Activity to Stabilize Protein and Facilitate Protein Refolding. CCS Chem. 2025, 7, 2185–2200.

41.  Wu, T.^#; Zhou, M.^#; Zou, J.; Chen, Q.; Qian, F.; Kurths, J.; Liu, R.*; Tang, Y.*  Few-shot Inverse Design of HDP-Mimicking Polymers against Drug-Resistant Bacteria, Nat. Commun, 2024, 15, 6288. (国基金委报导的基金资助重要成果)

40.  Wu, Y.*; Chen, K.; Wang, J.; Chen, M.; Dai, W.; Liu, R.*  Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization. J. Am. Chem. Soc., 2024, 146, 24189–24208

39.  Shao, N.; Yuan, L.; Liu, L.; Cong, Z.; Wang, J.; Wu, Y.; Liu, R.* Reversing Anticancer Drug Resistance by Synergistic Combination of Chemotherapeutics and Membranolytic Antitumor β-Peptide Polymer. J. Am. Chem. Soc. 2024, 146(16), 11254-11265.

38. Jiang, W.; Zhou, M.; Chen, S.; Xie, J.; Chen, M.; Zhang, H.; Wu, Y.; Chen, X.; Liu, R.* Peptide-mimicking poly(2-oxazoline)s possessing potent antifungal activity and BBB penetrating property to treat invasive infections and meningitis. J. Am. Chem. Soc. 2023, 145, 47, 25753–25765.

37. Chen, Q.; Zhang, X.; Zhang, D.; Liu, G.; Ma, K.; Liu, J.; Ma, K.; Chen, M.; Li, Y.; Liu, R.* Universal and one-step modification to render diverse materials bioactivation. J. Am. Chem. Soc. 2023, 145, 18084.

36. Wu, Y.; Chen, K.; Wang, J.; Chen, M.; Chen, Y.; She, Y.; Yan, Z.; Liu, R.* Host defense peptide mimicking antimicrobial amino acid polymers and beyond: design, synthesis and biomedical applications. Prog. Polym. Sci. 2023, 141, 101679.

35. Zhang, H.^#; Chen, Q.^#; Xie, J.^#; Cong, Z.; Cao, C.; Zhang, W.; Zhang, D.; Chen, S.; Gu, J.; Deng, S.; Qiao, Z.; Zhang, X.; Li, M.; Lu, Z.; Liu, R.* Switching from membrane disrupting to membrane crossing, an effective strategy in designing antibacterial polypeptide. Sci. Adv. 2023, 9(4), eabn0771.

34. Zhou, R.; Wu, Y.; Chen, K.; Zhang, D.; Chen, Q.; Zhang, D.; She, Y.; Zhang, W.; Liu, L.; Zhu, Y.; Gao, C.; Liu, R.* A Polymeric Strategy Empowering Vascular Cell Selectivity and Potential Application Superior to Extracellular Matrix Peptides. Adv. Mater. 2022, 34(42), e2200464.

33. Xiao, X.^#; Zhou, M.^#; Cong, Z.; Liu, L.; Zou, J.; Ji, Z.; Cui, R.; Wu, Y.; Zhang, H.; Chen, S.; Li, M.; Liu, R.* Controllable Polymerization of N-Substituted β-Alanine N-Thiocarboxyanhydrides for Convenient Synthesis of Functional Poly(β-peptoid)s. CCS Chemistry 2023, 5(4), 994-1004.

32. Wu, Y.^#; Jiang, W.^#; Cong, Z.; Chen, K.; She, Y.; Zhong, C.; Zhang, W.; Chen, M.; Zhou, M.; Shao, N.; Xiao, G.; Shao, X.; Dai, Y.; Fei, J.; Song, G.; Liu, R.* An Effective Strategy to Develop Potent and Selective Antifungal Agents from Cell Penetrating Peptides in Tackling Drug-Resistant Invasive Fungal Infections. J. Med. Chem. 2022, 65 (10), 7296–7311.

31. Zhang, W.; Wu, Y.; Chen, Q.; Zhang, H.; Zhou, M.; Chen, K.; Cao, C.; Guo, H.; Xu, J.; Liu, H.; Lin, H.; Liu, C.; Liu, R.*Statistic Copolymers Working as Growth Factor-Binding Mimics of Fibronectin. Adv. Sci. 2022, 9(21), 2200775.

30. Shao, N.; Yuan, L.; Ma, P.; Zhou, M.; Xiao, X.; Cong, Z.; Wu, Y.; Xiao, G.; Fei, J.; Liu, R.* Heterochiral β-Peptide Polymers Combating Multidrug-Resistant Cancers Effectively without Inducing Drug Resistance. J. Am. Chem. Soc. 2022, 144 (16), 7283-7294.

29. Zhang, D.; Shi, C; Cong, Z; Chen, Q; Bi, Y; Zhang, J; Ma, K; Liu, S; Gu. J; Chen, M; Lu, Z; Zhang, H; Xie, J; Xiao, X; Liu, L; Jiang, W; Shao, N; Chen, S; Zhou, M; Shao, X; Dai, Y; Li, M; Zhang, L; Liu, R.* Microbial Metabolite Inspired β-Peptide Polymers Displaying Potent and Selective Antifungal Activity. Adv. Sci. 2022, 2104871.

28. Jiang, W.^#; Zhou, M. ^#; Cong, Z.; Xie, J.; Zhang, W.; Chen, S.; Zou, J.; Ji, Z.; Shao, N.; Chen, X.; Li, M.; Liu, R.* Short Guanidinium-Functionalized Poly(2-oxazoline)s Displaying Potent Therapeutic Efficacy on Drug-Resistant Fungal Infections. Angew. Chem. Int. Ed. 2022, 61(17), e202200778

27. Wu, Y. ^#; Lin, Y. ^#; Cong, Z.; Chen, K.; Xiao, X.; Wu, X.; Liu, L.; She, Y.; Liu, S.; Zhou, R.; Yin, G.; Shao, X.; Dai, Y.; Lin, H.*; Liu R.* Peptide Polymer-Doped Cement Acting as an Effective Treatment of MRSA-Infected Chronic Osteomyelitis. Adv. Funct. Mater.2022, 32(7), 2107942.

26. Qian Y., Deng, S.,Cong Z., Zhang, H., Lu Z., Shao N., Bhatti S.A., Zhou C., Cheng J., GellmanS.H.*, and Liu R.* Secondary Amine Pendant β-peptide Polymers DisplayingPotent Antibacterial Activity and Promising Therapeutic Potential in TreatingMRSA-Induced Wound Infections and Keratitis. J. Am. Chem. Soc., 2022, 144(4), 1690–1699.

25. Zhang, D.#; Liu, J.#; Chen, Q.; Jiang, W.; Wang, Y.; Xie, J.; Ma, K.; Shi, C.; Zhang, H.; Chen, M.; Wan, J.; Ma, P.; Zou, J.; Zhang, W.; Zhou, F.; Liu, R.* A Sandcastle Worm-Inspired Strategy to Functionalize Wet Hydrogels. Nature Communications 2021, 12, 6331.

24. Wu, Y.; Chen, K.; Wu, X.; Liu, L.; Zhang, W.; Ding, Y.; Liu, S.; Zhou, M.; Shao, N.; Ji, Z.; Chen, J.; Zhu, M.; Liu, R.* Superfast and Water-Insensitive Polymerization on α-Amino Acid N-Carboxyanhydrides to Prepare Polypeptides using Tetraalkylammonium carboxylates as the Initiator. Angew. Chem. Int. Ed. 2021. 60, 26063-26071.

23. Xie, J.#; Zhou, M.#; Qian, Y.; Cong, Z.; Chen, S.; Zhang, W.; Jiang, W.;Dai, C.; Shao, N.; Ji, Z.; Zou, J.; Xiao, X.; Liu, L.; Chen, M.; Li, J.;Liu, R.* Addressing MRSA Infection andAntibacterial Resistance with Peptoid Polymers. Nature Communications 2021, 12, 5898.

‍(Highlighted by BioCentury Innovations)

22. Zhang, D.; Chen, Q.; Bi, Y.; Zhang, H.; Chen, M.; Wan, J.; Shi, C.; Zhang, W.; Zhang, J.; Qiao, Z.; Li, J.; Liu, Y.; Chen, S.; Liu, R.* Bio-Inspired Hydrogels Resist the Foreign-Body Response. Nature Communications  2021, 12, 5327.

(Highlighted by Etracellular Matrix News as TOP STORY)

21. Zhou, M.; Zou, J.; Liu, L.; Xiao,X.; Deng, S.; Wu, Y.; Xie, Jia.; Cong, Z.; Ji, Z.; Liu, R.*Synthesis of Poly-α/β-peptideswith Tunable Sequence Via the Copolymerization on N-carboxyanhydride and N-thiocarboxyanhydride. iScience, 2021, 24(10): 103124.

20. Chen, Q.; Zhang D.; ZhangW.; Zhang H.; Zou J.; ChenM.; LiJ.; Yuan Y.; Liu, R.*Dual mechanismβ-amino acid polymers ing cell adhesion. Nature Communications 2021, 12, 562

19. Zhang, D.; Chen, Q.; Shi, C.; Chen, M.; Ma, K.; Wan, J.; Liu, R.* Dealing with the Foreign-Body Response to Implanted Biomaterials: Strategies and Applications of New Materials. Adv. Funct. Mater. 2021, 31, 2007226.

18. Etayash, H.; Qian, Y.; Pletzer, D.; Zhang, Q.; Xie, J.; Cui, R.; Dai, C.; Ma, P.; Qi, F.; Liu, R.* Hancock, R. E. W.* Host Defense Peptide-Mimicking Amphiphilic beta-Peptide Polymer (Bu:DM) Exhibiting Anti-Biofilm, Immunomodulatory, and in Vivo Anti-Infective Activity. J. Med. Chem. 2020, 63, 12921-12928.

17. Zhang, D.; Chen, Q.; Zhang, W.; Liu, H.; Wan, J.; Qian, Y.; Li, B.; Tang, S.; Liu, Y.; Chen, S.; Liu, R.* Silk‐inspired β‐peptide Materials Resist Fouling and the Foreign‐body Response. Angew. Chem. Int. Ed. 2020, 59, 9586–9593.  (Hot Paper)

16. Zhou, M.; Xiao, X.; Cong, Z.; Wu, Y.; Zhang, W.; Ma, P.; Chen, S.; Zhang, H.; Zhang, D.; Zhang, D.; Luan, X.; Mai, Y.; Liu, R.* Water Insensitive Synthesis of Poly-beta-Peptides with Defined Architecture. Angew. Chem. Int. Ed. 2020,59, 7240-7244.‍

15. Zhou, M.; Qian, Y.; Xie, J.; Zhang, W.; Jiang, W.; Xiao, X.; Chen, S.; Dai, C.; Cong, Z.; Ji, Z.; Shao, N.; Liu, L.; Wu, Y.; Liu, R.* Poly(2‐Oxazoline) Based Functional Mimics of Peptides to Eradicate MRSA Infections and Persisters While Alleviating Antimicrobial Resistance. Angew. Chem. Int. Ed. 2020, 59, 6412-6419.  (VIP paper, Inside Cover, Highly Cited Paper)

14. Chen, Q.; Yu, S.; Zhang, D.; Zhang, W.; Zhang, H.; Zou, J.; Mao, Z.; Yuan, Y.; Gao C.; Liu, R.* Impact of Antifouling PEG Layer on the Performance of Functional Peptides in Regulating Cell Behaviors.  J. Am. Chem. Soc. 2019, 141, 16772

(Selected as the JACS supplementary cover)

(Highlighted by Sci. China Chem, 2019, DOI: 10.1007/s11426-019-9654-9)

(Highlighted by CCL, 2019, DOI: 10.1016/j.cclet.2019.10.038)

13. Wu, Y.; Zhang, D.; Ma, P.; Zhou, R.; Hua, L.; Liu, R.* Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides. Nat. Commun. 2018, 9 (1), 5297.

(Selected as the editor's choice)

(Spotlight by Acta Polymerica Sinica, 2019, 50(2): 99)

(Spotlight by J. Functional Polymers, 2019, 32(2): 120)

(Spotlight reviewed by Materials Reports, 2019, 33(1): 1)

12. Ding, X.; Duan, S.; Ding, X.; Liu, R.*; Xu, F.*, Versatile Antibacterial Materials: An Emerging Arsenal for Combatting Bacterial Pathogens. Adv. Funct. Mater. 2018, 28 (40), 19.  (Highly Cited Paper)

11. Qi. F; Qian, Y.; Shao, N.; Zhou, R.; Zhang, S.; Lu Z.; Zhou, M.; Xie, J.; Wei, T.; Yu, Q.;, Liu, R.*, Practical Preparation of Infection-Resistant Biomedical Surfaces from Antimicrobial β-Peptide Polymers. ACS Appl. Mater. Interfaces 2019, 11 (21), 18907-18913.

10. Qian, Y.; Qi, F.; Chen, Q.; Zhang, Q.; Qiao, Z.; Zhang, S.; Wei, T.; Yu, Q.; Yu, S.; Mao, Z.; Gao, C.; Ding, Y.; Cheng, Y.; Jin, C.; Xie, H.; Liu, R.* Surface Modified with a Host Defense Peptide-Mimicking beta-Peptide Polymer Kills Bacteria on Contact with High Efficacy. ACS Appl. Mater. Interfaces 2018, 10 (18), 15395-15400.

9. Liu, R.; Chen, X.; Falk, S.; Masters, K. S.; Weisblum, B.; Gellman, S. H. “Nylon-3 Polymers Active against Drug-Resistant Candida albicans Biofilms” J. Am. Chem. Soc. 2015, 137: 2183-2196.

8. Liu, R.; Chen, X.; Falk, S.; Mowery, B.; Karlsson, A.; Weisblum, B.; Palecek, S.; Masters, K. S.; Gellman, S. H. “Structure–Activity Relationships among Antifungal Nylon-3 Polymers:  Identification of Materials Active Against Drug-Resistant Strains of Candida albicans”, J. Am. Chem. Soc.2014, 136: 4333-4342.

(Highlighted by SciBX, SciBX 7(11), 2014, 315)

7. Liu, R.; Chen, X.; Chakraborty, S.; Lemke, J.; Hayouka, Z.; Chow, C.; Welch, R.; Weisblum, B.; Masters, K. S.; Gellman, S. H. “Tuning the Biological Activity Profile of Antibacterial Polymers via Subunit Substitution Pattern”, J. Am. Chem. Soc.2014, 136: 4410-4418.

(Highlighted by SciBX: SciBX 7(15), 2014, 441)

6. Liu, R.#; Suárez, J. M.#; Weisblum, B.; Gellman, S. H.; and McBride, S. M. “Polymers Active Against Clostridium difficile Vegetative Cell Growth and Spore Outgrowth.” J. Am. Chem. Soc. 2014, 136, 14498-14504. (equal contribution)

(Highlighted by SciBX: SciBX 7(43), 2014, 1263)

5. Chakraborty, S.#; Liu, R.#; Hayouka, Z.; Chen, X.; Ehrhardt, J.; Lu, Q.; Burke, E.; Yang, Y.; Weisblum, B.; Wong, G. C. L.; Masters, K. S; and Gellman, S. H. “Ternary nylon-3 copolymers as host-defense peptide mimics: beyond hydrophobic and cationic subunits.” J. Am. Chem. Soc.2014, 136, 14530-14535. (equal contribution)

4. Liu, R.; Chen, X.; Gellman, S. H.; Masters, K. S. “Nylon-3 Polymers that Enable Selective Culture of Endothelial Cells”,  J. Am. Chem. Soc. 2013, 135: 16296-16299.

3. Liu, R.; Chen, X.; Hayouka, Z.; Chakraborty, S.; Falk, S. P.; Weisblum, B.; Masters, K. S.; Gellman, S. H. “Nylon-3 Polymers with Selective Antifungal Activity.” J Am Chem Soc. 2013, 135, 5270-5273.

(Featured in JACS Spotlights, J. Am. Chem. Soc. 2013, 135: 5933−5933)

2. Hayouka, Z.; Chakraborty, S.; Liu, R.; Boersma, M. D.; Weisblum, B.; Gellman, S. H. “Interplay among Subunit Identity, Subunit Proportion, Chain Length, and Stereochemistry in the Activity Profile of Sequence-Random Peptide Mixtures.” J. Am. Chem. Soc. 2013, 135: 11748-11751.

1. Liu, R.; Chanthamontri, C.; Han, H.; Hernández-Torres, J.M.; Wood, K.V.; Mcluckey, S.A.; Wei, A. “Solid-Phase Synthesis of α-Glucosamine Sulfoforms with Fragmentation Analysis by Tandem Mass Spectrometry.” J. Org. Chem. 2008, 73: 6059-6072.  

(Featured Article)