刘润辉
发布人: 刘润辉 发布时间: 2019-12-09 作者: 访问次数: 115389


刘润辉    教授、博导、国家级青年高层次人才、上海市青年学术带头人

华东理工大学特聘教授

研究方向:高分子生物材料

Emailrliu@ecust.edu.cn       Tel: 021-64253402

办公室:徐汇校区科辅二楼二层C203   

邮政地址:上海市梅陇路130546信箱

招生专业:材料科学与工程

本课题组常年招收博士后;招收博士、硕士研究生

课题组开展交叉领域研究,欢迎对以下某个方向有兴趣的同学加入我们课题组: 有机合成、高分子、生物、微生物、肿瘤、免疫。

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教育及研究经历:

2004-2009 美国 普渡大学(Purdue University) 博士

2009-2010 美国 加州理工学院(California Institute of Technology) 博士后

2010-2014 美国 威斯康星大学麦迪逊校区(University of Wisconsin-Madison) 博士后

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主要研究方向:

模拟天然蛋白功能的合成高分子生物材料,包括:
 1.
功能化聚合物单体的合成;多功能高分子材料的制备及合成方法研究
 2.
生物相容、生物可降解高分子材料的研究与开发
 3.
抗细菌、抗真菌生物材料的研制与作用机理研究
 4.
具有细胞黏附、细胞选择功能的生物材料研究及在组织修复中的应用
 5.
抗非特异性蛋白吸附及微生物生物膜形成的防污材料研究及在生物医学工程领域的应用
 6.
蛋白类及小分子药物的体内传输和可控释放研究

 7. 抗肿瘤多肽研究

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代表性学术论文:

20. Chen, Q.; Zhang D.; ZhangW.; Zhang H.; Zou J.; ChenM.; LiJ.; Yuan Y.; Liu, R.*Dual mechanismβ-amino acid polymers promoting cell adhesion. Nature Communications 2021, 12, 562


19. Zhang, D.; Chen, Q.; Shi, C.; Chen, M.; Ma, K.; Wan, J.; Liu, R.* Dealing with the Foreign-Body Response to Implanted Biomaterials: Strategies and Applications of New Materials. Adv. Funct. Mater. DOI: 10.1002/adfm.202007226.


18. Etayash, H.; Qian, Y.; Pletzer, D.; Zhang, Q.; Xie, J.; Cui, R.; Dai, C.; Ma, P.; Qi, F.; Liu, R.* Hancock, R. E. W.* Host Defense Peptide-Mimicking Amphiphilic beta-Peptide Polymer (Bu:DM) Exhibiting Anti-Biofilm, Immunomodulatory, and in Vivo Anti-Infective Activity. J. Med. Chem. 2020, 63, 12921-12928.


17. Zhang, D.; Chen, Q.; Zhang, W.; Liu, H.; Wan, J.; Qian, Y.; Li, B.; Tang, S.; Liu, Y.; Chen, S.; Liu, R.* Silkinspired β‐peptide Materials Resist Fouling and the Foreignbody Response. Angew. Chem. Int. Ed. 2020, 59, 9586–9593.  (Hot Paper)


16. Zhou, M.; Xiao, X.; Cong, Z.; Wu, Y.; Zhang, W.; Ma, P.; Chen, S.; Zhang, H.; Zhang, D.; Zhang, D.; Luan, X.; Mai, Y.; Liu, R.* Water Insensitive Synthesis of Poly-beta-Peptides with Defined Architecture. Angew. Chem. Int. Ed. 2020,59, 7240-7244.


15. Zhou, M.; Qian, Y.; Xie, J.; Zhang, W.; Jiang, W.; Xiao, X.; Chen, S.; Dai, C.; Cong, Z.; Ji, Z.; Shao, N.; Liu, L.; Wu, Y.; Liu, R.* Poly(2Oxazoline) Based Functional Mimics of Peptides to Eradicate MRSA Infections and Persisters While Alleviating Antimicrobial Resistance. Angew. Chem. Int. Ed. 2020, 59, 6412-6419(VIP paper, Inside Cover, Highly Cited Paper)


14. Chen, Q.; Yu, S.; Zhang, D.; Zhang, W.; Zhang, H.; Zou, J.; Mao, Z.; Yuan, Y.; Gao C.; Liu, R.* Impact of Antifouling PEG Layer on the Performance of Functional Peptides in Regulating Cell Behaviors.  J. Am. Chem. Soc. 2019, 141, 16772

(Selected as the JACS supplementary cover)

(Highlighted by Sci. China Chem, 2019, DOI: 10.1007/s11426-019-9654-9)

(Highlighted by CCL, 2019, DOI: 10.1016/j.cclet.2019.10.038)


13. Wu, Y.; Zhang, D.; Ma, P.; Zhou, R.; Hua, L.; Liu, R.* Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides. Nat. Commun. 2018, 9 (1), 5297.

(Selected as the editor's choice)

(Spotlight by Acta Polymerica Sinica, 2019, 50(2): 99)

(Spotlight by J. Functional Polymers, 2019, 32(2): 120)

(Spotlight reviewed by Materials Reports, 2019, 33(1): 1)


12. Ding, X.; Duan, S.; Ding, X.; Liu, R.*; Xu, F.*, Versatile Antibacterial Materials: An Emerging Arsenal for Combatting Bacterial Pathogens. Adv. Funct. Mater. 2018, 28 (40), 19.  (Highly Cited Paper)


11. Qi. F; Qian, Y.; Shao, N.; Zhou, R.; Zhang, S.; Lu Z.; Zhou, M.; Xie, J.; Wei, T.; Yu, Q.;, Liu, R.*, Practical Preparation of Infection-Resistant Biomedical Surfaces from Antimicrobial β-Peptide Polymers. ACS Appl. Mater. Interfaces 2019, 11 (21), 18907-18913.


10. Qian, Y.; Qi, F.; Chen, Q.; Zhang, Q.; Qiao, Z.; Zhang, S.; Wei, T.; Yu, Q.; Yu, S.; Mao, Z.; Gao, C.; Ding, Y.; Cheng, Y.; Jin, C.; Xie, H.; Liu, R.* Surface Modified with a Host Defense Peptide-Mimicking beta-Peptide Polymer Kills Bacteria on Contact with High Efficacy. ACS Appl. Mater. Interfaces 2018, 10 (18), 15395-15400.


9. Liu, R.; Chen, X.; Falk, S.; Masters, K. S.; Weisblum, B.; Gellman, S. H. “Nylon-3 Polymers Active against Drug-Resistant Candida albicans Biofilms” J. Am. Chem. Soc. 2015, 137: 2183-2196.


8. Liu, R.; Chen, X.; Falk, S.; Mowery, B.; Karlsson, A.; Weisblum, B.; Palecek, S.; Masters, K. S.; Gellman, S. H. “Structure–Activity Relationships among Antifungal Nylon-3 Polymers:  Identification of Materials Active Against Drug-Resistant Strains of Candida albicans”, J. Am. Chem. Soc.2014, 136: 4333-4342.

(Highlighted by SciBX, SciBX 7(11), 2014, 315)


7. Liu, R.; Chen, X.; Chakraborty, S.; Lemke, J.; Hayouka, Z.; Chow, C.; Welch, R.; Weisblum, B.; Masters, K. S.; Gellman, S. H. “Tuning the Biological Activity Profile of Antibacterial Polymers via Subunit Substitution Pattern”, J. Am. Chem. Soc.2014, 136: 4410-4418.

(Highlighted by SciBX: SciBX 7(15), 2014, 441)


6. Liu, R.#; Suárez, J. M.#; Weisblum, B.; Gellman, S. H.; and McBride, S. M. “Polymers Active Against Clostridium difficile Vegetative Cell Growth and Spore Outgrowth.” J. Am. Chem. Soc. 2014, 136, 14498-14504. (equal contribution)

(Highlighted by SciBX: SciBX 7(43), 2014, 1263)


5. Chakraborty, S.#; Liu, R.#; Hayouka, Z.; Chen, X.; Ehrhardt, J.; Lu, Q.; Burke, E.; Yang, Y.; Weisblum, B.; Wong, G. C. L.; Masters, K. S; and Gellman, S. H. “Ternary nylon-3 copolymers as host-defense peptide mimics: beyond hydrophobic and cationic subunits.” J. Am. Chem. Soc.2014, 136, 14530-14535. (equal contribution)


4. Liu, R.; Chen, X.; Gellman, S. H.; Masters, K. S. “Nylon-3 Polymers that Enable Selective Culture of Endothelial Cells”,  J. Am. Chem. Soc. 2013, 135: 16296-16299.


3. Liu, R.; Chen, X.; Hayouka, Z.; Chakraborty, S.; Falk, S. P.; Weisblum, B.; Masters, K. S.; Gellman, S. H. “Nylon-3 Polymers with Selective Antifungal Activity.” J Am Chem Soc. 2013, 135, 5270-5273.

(Featured in JACS Spotlights, J. Am. Chem. Soc. 2013, 135: 5933−5933)


2. Hayouka, Z.; Chakraborty, S.; Liu, R.; Boersma, M. D.; Weisblum, B.; Gellman, S. H. “Interplay among Subunit Identity, Subunit Proportion, Chain Length, and Stereochemistry in the Activity Profile of Sequence-Random Peptide Mixtures.” J. Am. Chem. Soc. 2013, 135: 11748-11751.


1. Liu, R.; Chanthamontri, C.; Han, H.; Hernández-Torres, J.M.; Wood, K.V.; Mcluckey, S.A.; Wei, A. “Solid-Phase Synthesis of α-Glucosamine Sulfoforms with Fragmentation Analysis by Tandem Mass Spectrometry.” J. Org. Chem. 2008, 73: 6059-6072.  

(Featured Article)