刘润辉
发布时间:2019-12-09   访问次数:130858   作者:网站管理员


刘润辉    教授、博导国家杰出青年科学基金

                上海市青年术带头人、东方学者、霍尼韦尔学者

研究方向:高分子合成、高分子生物材料、组织修复、抗菌材料、药物递送、抗肿瘤

Emailrliu@ecust.edu.cn       Tel: 021-64253402

办公室:徐汇校区科辅二楼二层C203   

邮政地址:上海市梅陇路130546信箱

招生专业:材料科学与工程

本课题组常年招收博士后招收博士硕士研究生

开展交叉领域研究,欢迎对以下某个方向有兴趣的同学加入课题组: 有机合成、高分子、合成生物学、微生物、肿瘤、免疫。

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教育及研究经历:

2004-2009 美国 普渡大学(Purdue University) 博士

2009-2010 美国 加州理工学院(California Institute of Technology) 博士后

2010-2014 美国 威斯康星大学麦迪逊校区(University of Wisconsin-Madison) 博士后

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主要研究方向:


模拟天然蛋白/多肽功能的高分子生物材料,包括:


  1. 高分子合成(多肽和多糖聚合物合成)

  2. 抗菌生物材料和抗菌药物研究

  3. 细胞黏附功能生物材料及组织修复研究

  4. 抗非特异性蛋白吸附材料及在生物医学工程领域的应用

  5. 药物的体内传输和可控释放研究

  6. 抗肿瘤多肽研究

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代表性学术论文:


38. Jiang, W.; Zhou, M.; Chen, S.; Xie, J.; Chen, M.; Zhang, H.; Wu, Y.; Chen, X.; Liu, R.* Peptide-mimicking poly(2-oxazoline)s possessing potent antifungal activity and BBB penetrating property to treat invasive infections and meningitis. J. Am. Chem. Soc. 2023, accepted



37. Chen, Q.; Zhang, X.; Zhang, D.; Liu, G.; Ma, K.; Liu, J.; Ma, K.; Chen, M.; Li, Y.; Liu, R.*Universal and one-step modification to render diverse materials bioactivation. J. Am. Chem. Soc. 2023145, 18084.



36. Wu, Y.; Chen, K.; Wang, J.; Chen, M.; Chen, Y.; She, Y.; Yan, Z.; Liu, R.* Host defense peptide mimicking antimicrobial amino acid polymers and beyond: design, synthesis and biomedical applications. Prog. Polym. Sci. 2023, 141, 101679.



35. Zhang, H.#; Chen, Q.#; Xie, J.#; Cong, Z.; Cao, C.; Zhang, W.; Zhang, D.; Chen, S.; Gu, J.; Deng, S.; Qiao, Z.; Zhang, X.; Li, M.; Lu, Z.; Liu, R.* Switching from membrane disrupting to membrane crossing, an effective strategy in designing antibacterial polypeptide. Sci. Adv. 2023, 9(4), eabn0771.



34. Zhou, R.; Wu, Y.; Chen, K.; Zhang, D.; Chen, Q.; Zhang, D.; She, Y.; Zhang, W.; Liu, L.; Zhu, Y.; Gao, C.; Liu, R.* A Polymeric Strategy Empowering Vascular Cell Selectivity and Potential Application Superior to Extracellular Matrix Peptides. Adv. Mater. 2022, 34(42), e2200464.



33. Xiao, X.#; Zhou, M.#; Cong, Z.; Liu, L.; Zou, J.; Ji, Z.; Cui, R.; Wu, Y.; Zhang, H.; Chen, S.; Li, M.; Liu, R.* Controllable Polymerization of N-Substituted β-Alanine N-Thiocarboxyanhydrides for Convenient Synthesis of Functional Poly(β-peptoid)s. CCS Chemistry 2023, 5(4), 994-1004.



32. Wu, Y.#; Jiang, W.#; Cong, Z.; Chen, K.; She, Y.; Zhong, C.; Zhang, W.; Chen, M.; Zhou, M.; Shao, N.; Xiao, G.; Shao, X.; Dai, Y.; Fei, J.; Song, G.; Liu, R.* An Effective Strategy to Develop Potent and Selective Antifungal Agents from Cell Penetrating Peptides in Tackling Drug-Resistant Invasive Fungal Infections. J. Med. Chem. 2022, 65 (10), 7296–7311.



31. Zhang, W.; Wu, Y.; Chen, Q.; Zhang, H.; Zhou, M.; Chen, K.; Cao, C.; Guo, H.; Xu, J.; Liu, H.; Lin, H.; Liu, C.; Liu, R.*Statistic Copolymers Working as Growth Factor-Binding Mimics of Fibronectin. Adv. Sci. 2022, 9(21), 2200775.



30. Shao, N.; Yuan, L.; Ma, P.; Zhou, M.; Xiao, X.; Cong, Z.; Wu, Y.; Xiao, G.; Fei, J.; Liu, R.* Heterochiral β-Peptide Polymers Combating Multidrug-Resistant Cancers Effectively without Inducing Drug Resistance. J. Am. Chem. Soc. 2022, 144 (16), 7283-7294.



29. Zhang, D.; Shi, C; Cong, Z; Chen, Q; Bi, Y; Zhang, J; Ma, K; Liu, S; Gu. J; Chen, M; Lu, Z; Zhang, H; Xie, J; Xiao, X; Liu, L; Jiang, W; Shao, N; Chen, S; Zhou, M; Shao, X; Dai, Y; Li, M; Zhang, L; Liu, R.* Microbial Metabolite Inspired β-Peptide Polymers Displaying Potent and Selective Antifungal Activity. Adv. Sci. 2022, 2104871.



28. Jiang, W.#; Zhou, M. #; Cong, Z.; Xie, J.; Zhang, W.; Chen, S.; Zou, J.; Ji, Z.; Shao, N.; Chen, X.; Li, M.; Liu, R.* Short Guanidinium-Functionalized Poly(2-oxazoline)s Displaying Potent Therapeutic Efficacy on Drug-Resistant Fungal Infections. Angew. Chem. Int. Ed. 2022, 61(17), e202200778



27. Wu, Y. #; Lin, Y. #; Cong, Z.; Chen, K.; Xiao, X.; Wu, X.; Liu, L.; She, Y.; Liu, S.; Zhou, R.; Yin, G.; Shao, X.; Dai, Y.; Lin, H.*; Liu R.* Peptide Polymer-Doped Cement Acting as an Effective Treatment of MRSA-Infected Chronic Osteomyelitis. Adv. Funct. Mater.2022, 32(7), 2107942.



26. Qian Y., Deng, S.,Cong Z., Zhang, H., Lu Z., Shao N., Bhatti S.A., Zhou C., Cheng J., GellmanS.H.*, and Liu R.* Secondary Amine Pendant β-peptide Polymers DisplayingPotent Antibacterial Activity and Promising Therapeutic Potential in TreatingMRSA-Induced Wound Infections and Keratitis. J. Am. Chem. Soc., 2022, 144(4), 1690–1699.



25. Zhang, D.#; Liu, J.#; Chen, Q.; Jiang, W.; Wang, Y.; Xie, J.; Ma, K.; Shi, C.; Zhang, H.; Chen, M.; Wan, J.; Ma, P.; Zou, J.; Zhang, W.; Zhou, F.; Liu, R.* A Sandcastle Worm-Inspired Strategy to Functionalize Wet Hydrogels. Nature Communications 2021, 12, 6331.


24. Wu, Y.; Chen, K.; Wu, X.; Liu, L.; Zhang, W.; Ding, Y.; Liu, S.; Zhou, M.; Shao, N.; Ji, Z.; Chen, J.; Zhu, M.; Liu, R.* Superfast and Water-Insensitive Polymerization on α-Amino Acid N-Carboxyanhydrides to Prepare Polypeptides using Tetraalkylammonium carboxylates as the Initiator. Angew. Chem. Int. Ed. 2021. 60, 26063-26071.



23. Xie, J.#; Zhou, M.#; Qian, Y.; Cong, Z.; Chen, S.; Zhang, W.; Jiang, W.;Dai, C.; Shao, N.; Ji, Z.; Zou, J.; Xiao, X.; Liu, L.; Chen, M.; Li, J.;Liu, R.* Addressing MRSA Infection andAntibacterial Resistance with Peptoid Polymers. Nature Communications 2021, 12, 5898.

(Highlighted by BioCentury Innovations)



22. Zhang, D.; Chen, Q.; Bi, Y.; Zhang, H.; Chen, M.; Wan, J.; Shi, C.; Zhang, W.; Zhang, J.; Qiao, Z.; Li, J.; Liu, Y.; Chen, S.; Liu, R.* Bio-Inspired Hydrogels Resist the Foreign-Body Response. Nature Communications  2021, 12, 5327.

(Highlighted by Etracellular Matrix News as TOP STORY)


21. Zhou, M.; Zou, J.; Liu, L.; Xiao,X.; Deng, S.; Wu, Y.; Xie, Jia.; Cong, Z.; Ji, Z.; Liu, R.*Synthesis of Poly-α/β-peptideswith Tunable Sequence Via the Copolymerization on N-carboxyanhydride and N-thiocarboxyanhydride. iScience, 2021, 24(10): 103124.


20. Chen, Q.; Zhang D.; ZhangW.; Zhang H.; Zou J.; ChenM.; LiJ.; Yuan Y.; Liu, R.*Dual mechanismβ-amino acid polymers promoting cell adhesion. Nature Communications 2021, 12, 562


19. Zhang, D.; Chen, Q.; Shi, C.; Chen, M.; Ma, K.; Wan, J.; Liu, R.* Dealing with the Foreign-Body Response to Implanted Biomaterials: Strategies and Applications of New Materials. Adv. Funct. Mater. 2021, 31, 2007226.


18. Etayash, H.; Qian, Y.; Pletzer, D.; Zhang, Q.; Xie, J.; Cui, R.; Dai, C.; Ma, P.; Qi, F.; Liu, R.* Hancock, R. E. W.* Host Defense Peptide-Mimicking Amphiphilic beta-Peptide Polymer (Bu:DM) Exhibiting Anti-Biofilm, Immunomodulatory, and in Vivo Anti-Infective Activity. J. Med. Chem. 2020, 63, 12921-12928.


17. Zhang, D.; Chen, Q.; Zhang, W.; Liu, H.; Wan, J.; Qian, Y.; Li, B.; Tang, S.; Liu, Y.; Chen, S.; Liu, R.* Silkinspired β‐peptide Materials Resist Fouling and the Foreignbody Response. Angew. Chem. Int. Ed. 2020, 59, 9586–9593.  (Hot Paper)


16. Zhou, M.; Xiao, X.; Cong, Z.; Wu, Y.; Zhang, W.; Ma, P.; Chen, S.; Zhang, H.; Zhang, D.; Zhang, D.; Luan, X.; Mai, Y.; Liu, R.* Water Insensitive Synthesis of Poly-beta-Peptides with Defined Architecture. Angew. Chem. Int. Ed. 2020,59, 7240-7244.


15. Zhou, M.; Qian, Y.; Xie, J.; Zhang, W.; Jiang, W.; Xiao, X.; Chen, S.; Dai, C.; Cong, Z.; Ji, Z.; Shao, N.; Liu, L.; Wu, Y.; Liu, R.* Poly(2Oxazoline) Based Functional Mimics of Peptides to Eradicate MRSA Infections and Persisters While Alleviating Antimicrobial Resistance. Angew. Chem. Int. Ed. 2020, 59, 6412-6419(VIP paper, Inside Cover, Highly Cited Paper)



14. Chen, Q.; Yu, S.; Zhang, D.; Zhang, W.; Zhang, H.; Zou, J.; Mao, Z.; Yuan, Y.; Gao C.; Liu, R.* Impact of Antifouling PEG Layer on the Performance of Functional Peptides in Regulating Cell Behaviors.  J. Am. Chem. Soc. 2019, 141, 16772

(Selected as the JACS supplementary cover)

(Highlighted by Sci. China Chem, 2019, DOI: 10.1007/s11426-019-9654-9)

(Highlighted by CCL, 2019, DOI: 10.1016/j.cclet.2019.10.038)


13. Wu, Y.; Zhang, D.; Ma, P.; Zhou, R.; Hua, L.; Liu, R.* Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides. Nat. Commun. 2018, 9 (1), 5297.

(Selected as the editor's choice)

(Spotlight by Acta Polymerica Sinica, 2019, 50(2): 99)

(Spotlight by J. Functional Polymers, 2019, 32(2): 120)

(Spotlight reviewed by Materials Reports, 2019, 33(1): 1)


12. Ding, X.; Duan, S.; Ding, X.; Liu, R.*; Xu, F.*, Versatile Antibacterial Materials: An Emerging Arsenal for Combatting Bacterial Pathogens. Adv. Funct. Mater. 2018, 28 (40), 19.  (Highly Cited Paper)


11. Qi. F; Qian, Y.; Shao, N.; Zhou, R.; Zhang, S.; Lu Z.; Zhou, M.; Xie, J.; Wei, T.; Yu, Q.;, Liu, R.*, Practical Preparation of Infection-Resistant Biomedical Surfaces from Antimicrobial β-Peptide Polymers. ACS Appl. Mater. Interfaces 2019, 11 (21), 18907-18913.


10. Qian, Y.; Qi, F.; Chen, Q.; Zhang, Q.; Qiao, Z.; Zhang, S.; Wei, T.; Yu, Q.; Yu, S.; Mao, Z.; Gao, C.; Ding, Y.; Cheng, Y.; Jin, C.; Xie, H.; Liu, R.* Surface Modified with a Host Defense Peptide-Mimicking beta-Peptide Polymer Kills Bacteria on Contact with High Efficacy. ACS Appl. Mater. Interfaces 2018, 10 (18), 15395-15400.


9. Liu, R.; Chen, X.; Falk, S.; Masters, K. S.; Weisblum, B.; Gellman, S. H. “Nylon-3 Polymers Active against Drug-Resistant Candida albicans Biofilms” J. Am. Chem. Soc. 2015, 137: 2183-2196.


8. Liu, R.; Chen, X.; Falk, S.; Mowery, B.; Karlsson, A.; Weisblum, B.; Palecek, S.; Masters, K. S.; Gellman, S. H. “Structure–Activity Relationships among Antifungal Nylon-3 Polymers:  Identification of Materials Active Against Drug-Resistant Strains of Candida albicans”, J. Am. Chem. Soc.2014, 136: 4333-4342.

(Highlighted by SciBX, SciBX 7(11), 2014, 315)


7. Liu, R.; Chen, X.; Chakraborty, S.; Lemke, J.; Hayouka, Z.; Chow, C.; Welch, R.; Weisblum, B.; Masters, K. S.; Gellman, S. H. “Tuning the Biological Activity Profile of Antibacterial Polymers via Subunit Substitution Pattern”, J. Am. Chem. Soc.2014, 136: 4410-4418.

(Highlighted by SciBX: SciBX 7(15), 2014, 441)


6. Liu, R.#; Suárez, J. M.#; Weisblum, B.; Gellman, S. H.; and McBride, S. M. “Polymers Active Against Clostridium difficile Vegetative Cell Growth and Spore Outgrowth.” J. Am. Chem. Soc. 2014, 136, 14498-14504. (equal contribution)

(Highlighted by SciBX: SciBX 7(43), 2014, 1263)


5. Chakraborty, S.#; Liu, R.#; Hayouka, Z.; Chen, X.; Ehrhardt, J.; Lu, Q.; Burke, E.; Yang, Y.; Weisblum, B.; Wong, G. C. L.; Masters, K. S; and Gellman, S. H. “Ternary nylon-3 copolymers as host-defense peptide mimics: beyond hydrophobic and cationic subunits.” J. Am. Chem. Soc.2014, 136, 14530-14535. (equal contribution)


4. Liu, R.; Chen, X.; Gellman, S. H.; Masters, K. S. “Nylon-3 Polymers that Enable Selective Culture of Endothelial Cells”,  J. Am. Chem. Soc. 2013, 135: 16296-16299.


3. Liu, R.; Chen, X.; Hayouka, Z.; Chakraborty, S.; Falk, S. P.; Weisblum, B.; Masters, K. S.; Gellman, S. H. “Nylon-3 Polymers with Selective Antifungal Activity.” J Am Chem Soc. 2013, 135, 5270-5273.

(Featured in JACS Spotlights, J. Am. Chem. Soc. 2013, 135: 5933−5933)


2. Hayouka, Z.; Chakraborty, S.; Liu, R.; Boersma, M. D.; Weisblum, B.; Gellman, S. H. “Interplay among Subunit Identity, Subunit Proportion, Chain Length, and Stereochemistry in the Activity Profile of Sequence-Random Peptide Mixtures.” J. Am. Chem. Soc. 2013, 135: 11748-11751.


1. Liu, R.; Chanthamontri, C.; Han, H.; Hernández-Torres, J.M.; Wood, K.V.; Mcluckey, S.A.; Wei, A. “Solid-Phase Synthesis of α-Glucosamine Sulfoforms with Fragmentation Analysis by Tandem Mass Spectrometry.” J. Org. Chem. 2008, 73: 6059-6072.  

(Featured Article)