报告人：Guang-Xian Zhang教授(Thomas Jefferson University)
报告题目：自体神经干细胞-鸡尾酒疗法促进中枢神经系统再生
报告时间：2016年4月10日 14:00-15:00
报告地点：实验15楼7楼会议室
 
联系人：李玉林(实验15楼724)

 
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Guang-Xian Zhang教授简介：

        Guang-Xian Zhan于1997年在瑞典卡罗林斯卡医学院获得神经病学专业博士学位，之后在美国费城宾夕法尼亚大学做博士后研究；2003起任托马斯o杰弗逊大学医学院神经病学助理教授，副教授、及神经免疫实验室主任至今，2012年10月至今任神经病学教授。这次Guang-Xian Zhang教授将为我们做题目为“A triple molecular cocktail produced by neural stem cells: a novel neurorepair therapy for chronic stage CNS autoimmunity”的报告，其摘要如下：
 
报告摘要：

        Treatment of chronic neurodegenerative diseases such as multiple sclerosis (MS), chronic stage in particular, remains a major challenge. Persistent inflammation in the central nervous system (CNS), loss of trophic support for both oligodendrocytes and neurons, and accumulation of CNS regeneration inhibitors are three major mechanisms contribute to the chronicity of MS and its animal model, experimental autoimmune encephalomyelitis (EAE). While injection of un-modified NSCs suppressed EAE at acute stage of disease, these cells fail to do so when injected at chronic stage of disease, e.g., 60 days post immunization. Here we genetically engineered bone marrow-derived neural stem cells (BM-NSCs) simultaneously producing a therapeutic cocktail including neurotrophin 3 (NT-3), a potent neurotrophic factor, interleukin 10 (IL-10), an effective immunoregulatory cytokine, and soluble LINGO-1 protein (LINGO-1-Fc), an antagonist of neuroregeneration inhibitors, under control of the Tet-on system. While slight recovery was observed in mice received NSCs transduced with one or two of these genes, NSCs transduced with all three genes, which produced a mixture of all three therapeutic proteins (cocktail), effectively ameliorated clinical disease severity and CNS inflammation, enhanced MBP synthesis, protected axonal integrity, and suppressed astrogliosis. Further, the mixture of these three molecules (cocktail) converts the hostile environment into one supportive of the neuroregenerative process, thus promoting endogenous oligodendrocyte/neuron differentiation and axonal integrity. Together, this genetically modified cocktail-NSC system simultaneously targets the three major mechanisms underlying the pathogenesis of MS and EAE, thus representing a novel, easily accessible, autologous and highly effective therapy for the chronic stage of EAE and, potentially, MS.