主要研究方向：

 李教授长期致力于可吸收医用高分子与医疗器械的应用研究。以第一/通讯作者在Chem. Rev., Adv. Funct. Mater., Biomaterials,ACS Nano等学术刊物发表文章150余篇，申请（授权）发明专利10余项（1项PCT专利）。担任International Journal of Molecular Sciences和Gels等国际SCI学术期刊的客座编辑。承担国家重点研发计划课题1项、国家重点研发计划子课题2项、军委科技委项目、国家自然科学基金面上项目2项、及省部级项目十余项，获上海市人才发展基金和瓯越海智英才计划资助。

 在产业化方面，针对医用原料与器械的“卡脖子”技术瓶颈问题，李教授聚焦医药用聚乳酸原料、可吸收医疗器械开发、注册全过程，作为创始人于2022年创立浙江佰麟生物科技有限公司，建立完善的“合成方法-工艺路线-放大过程-医学转化”研发平台和专业产线，建立了医用原料到医疗器械工程创新全链条产业，带领研发团队设计开发了50多种可吸收聚乳酸医用级原料，实现医用聚乳酸原料国产化，并入选“浙江创新馆核心展品”；注重从源头到终端产品全链条研发技术，攻克了高强度可吸收自增强骨钉关键技术，产品强度优于美国强生等主流进口临床竞品，该成果入选2022年“科创中国”先导技术，并荣获2021年国际高新技术成果交易会展优秀产品奖和上海市科学进步一等奖；所研制的聚乳酸凝胶产品已获批首张含有聚乳酸可吸收微球导光凝胶（浙温械备20230047）；研制了2种兽药纳米制剂，建立了1条可吸收微球管线和年产10万片新芙蓉膏贴产线，作为院内制剂辐射上万次乳腺炎患者。

人才培养与国际交流：

 担任高材161和材料2002班班导师，指导2项USRP和4项大学生创新项目。分别指导大学生获得第一届上海市大学生生命科学竞赛三等奖、第十三届“华陆科技·奋进杯”大学生课外学术科技作品竞赛二等奖等。自2014年以来指导研究生28名，其中6名硕士研究生（许欣、罗炜、郑玲、张世豪等）获得国家奖学金、1名博士研究生（王宜峰）获校优秀学生称号、4名硕士研究生（郑玲、蔡佩昊、林安琪等）获得校优秀毕业生称号，20余名硕士研究生（王雅琪、郑玲、罗炜、陈璨、许梦瑶、林安琪、蔡佩昊、李煦等）获校一等奖学金。分别指导研究生获得第三届国际纳米药物大会JACS最佳墙报奖（郑玲）、中国生物材料大会产业化论坛创新创业大赛三等奖、第二届青年学术论文优秀奖评选一等奖（罗炜）、2021生物材料大会优秀墙报奖（蔡佩昊）、2023生物材料大会优秀墙报奖（赵政）。积极参与包括“111”引智计划在内的国际学术交流活动，注重具有国际视野的材料领域年轻人才培养，指导2名学生（刘天舒、陈占立）获得国家奖学金赴澳留学。

主要经历与简历：

1995/9 - 1999/6  湖北大学，化学与材料科学学院，学士

1999/9 - 2002/6  湖北大学，化学与材料科学学院，硕士

2002/9 - 2005/7  中国科学院，化学研究所 ，博士

2005/9 - 2006/7  法国里尔科技大学，固态结构与性能实验室，访问学者

2006/8 - 2008/3  日本国立物质材料研究所，生物材料中心，博士后

2008/5 - 2009/7  日本九州大学，应用化学系，Global-COE博士后

2009/7 - 2014/5  葡萄牙马德拉大学，化学与物质研究中心，研究助理教授

2014/6 – 2024/1  华东理工大学，材料科学与工程学院，副研究员

2024/2 – 至  今  华东理工大学，材料科学与工程学院，教授

2021/4 – 至  今  上海大学温州研究院，副院长

代表性科研项目:

1. 生物可吸收高分子基纳米活性材料及植入器械制备技术（课题负责人 / 274.0万元 / 2019-2024）/国家重点研发计划

2. 高品质聚乳酸纤维及其纺织品规模化制备与应用（子课题负责人/ 80.0万元 / 2017-2021）/国家重点研发计划

3. 新型高强度可吸收复合生物活性骨固定器械研发（子课题负责人/ 100.0万元 / 2022-2027）/国家重点研发计划

4. JG（**急救**技术研究）（主持 / 130.0万元 / 2022-2023）/军委科技委项目

5. 生物合成高性能聚乳酸纤维的研制及基础研究（主持 / 100.0万元 / 2025-2028）/上海科学技术委员会

6. 非细胞型活性仿生支架促进老年骨损伤修复应用研究（主持 / 62.0万元 / 2020-2023）/国家自然科学基面上项目

7. 兼具干细胞募集能力和成骨诱导功能的微纳结构活性材料的构建及快速成骨机制研究（主持 / 66.0万元 / 2020-2023）/国家自然科学基面上项目

8. 纳米控释材料开发（主持 / 300.0万元 / 2021-2022）/华东理工大学—郑州赛科药业科技有限公司技术开发项目

9. 医用敷料的原料应用性探索（主持 / 50.0万元 / 2025-2027）/华东理工大学—万华化学集团股份有限公司技术开发项目

10. 科学技术服务项目（主持 / 45.0万元 / 2023-2024）/华东理工大学—温州市瓯海区科学技术局

11. 兼具成血管能力的水凝胶联合基因工程化内源性脂肪干细胞治疗脊髓损伤研究（主持 / 40.0万元 / 2018-2021）/上海市科委港澳台科技合作项目

12. 基于微纳结构的高弹高强复合活性骨修复材料的研究 （主持 / 10.0万元 / 2015-2017）/上海市国际科技合作基金

13. 强度可控的多级微纳结构活性支架材料与生长因子协同骨修复研究 （主持 / 30.0万元 / 2015-2017）/上海市国际科技合作基金

14. 基于3D打印技术构建高强度活性支架材料与生长因子协同骨修复研究（主持 / 10.0万元 / 2015-2017）/上海市人才发展基金

15. 仿生骨多级结构活性支架材料的构建及促进骨组织快速修复的研究（主持 / 16.0万元 / 2017-2018）/教育部基本科研业务费

16. Self-assembled Nanoparticles based on PEG-PLA-dendrimer building blocks for dual gene/drug delivery（主持 / 15.7万欧 / 2012-2015）/葡萄牙科技部纳米专项

近期代表性论文:

1.Li, Yulin, Ruiying He, Yu Huang, Tinglin Zhang, Lan Xiao, Yin Xiao, Haifeng Liu et al. A 3R (remove-remodel-repair)-integrated self-assembled Chlorella-gelatin-PEG hydrogel for diabetic wound healing. Materials Today Bio (2025): 101935. (IF=10.2)

2.Ruixian LianDong ZhouLan XiaoJoão RodriguesRuilong ShengZhishan Bai*Yulin Li*Changsheng Liu*. PLLA–PEG/mPEG Copolymer with Improved Hydrophilicity, Crystallinity, and Biocompatibility: An In-Depth Study on the Crystallization Kinetics[J]. ACS Appl. Mater. Interfaces 2025, 17, 20, 30067-30080. (IF=8.2)

3.Shuyan Zhang, Lei Huang, Weisin Chen, Qi Chen, Xin Liu, Dihan Su, Lan Xiao, Dong Zhou*, Jian Zhang*, Libo Jiang*, and Yulin Li*. Piezoelectric hydrogel with self-powered biomechanical stimulation enhances bone regeneration [J]. Acta Biomaterialia, 2025, 195: 117-133. (IF=9.6)

4.Wenhao Yu, Dong Zhou, Fangrui Liu, Xu Li, Lan Xiao, Muhammad Rafique, Zhiyong Li, Joao Rodrigues, Ruilong Sheng, Yulin Li. Conjugation of PDLA onto MgO microspheres: comparison between solution grafting and melt grafting methods[J]. Journal of Materials Chemistry B, 2025, 13, 2674-2681. (IF=5.7)

5.Weisin Chen, Hongwei Lu, Wenhao Yu, Lei Huang, Mengxuan Bian, Ning Wang , Xingdong Xiang, Guokang Mo, Cheng Zhang , Yulin Li, Libo Jiang, Jian Zhang. Magnesium-Impregnated Membrane Promotes Bone Regeneration in Rat Skull Defect by N-Linked Glycosylation of SPARC via MagT1. Adv. Healthcare Mater, 2024, 2402705. (IF=9.6)

6.Bozhen Wu, Peng Wu, Yujing Yu, Yidong Wu, Xuejiao Song, Dong Zhou, Yulin Li. Flexible intelligent electromagnetic shielding polymer composites with sensitive on/off switching and high absorption. J. Mater. Chem. A, 2024,12, 29211-29221. (IF=9.5)

7.Shihao Zhang, Lei Huang, Mengxuan Bian, Lan Xiao, Dong Zhou, Ziwei Tao, Zheng Zhao,  Jian Zhang,  Li-Bo Jiang,  Yulin Li. Multifunctional Bone Regeneration Membrane with Flexibility, Electrical Stimulation Activity and Osteoinductive Activity. Small 2024, 2405311. (IF=12.1)

8.Yan Wu, Meiyun Li, Ruiying He, Lan Xiao, Sen Liu, Kaiyuan Chen, Huifen Qiang, Keqin Ji, Luxin Li, Yongkui Yin, Xiaohuan Yuan, Meng Li, Jie Gao, Yulin Li, Photosynthetic live microorganism-incorporated hydrogels e diabetic wound healing via self-powering and oxygen production, Chemical Engineering Journal,2024,485, 149545. (IF=13.2)

9.Yuhao Kang, Liren Wang, Shihao Zhang, Bowen Liu, Haihan Gao, Haocheng Jin,Lan Xiao, Guoyang Zhang, Yulin Li,Jia Jiang, and Jinzhong Zhao. Bioactive Patch for Rotator Cuff Repairing via Enhancing Tendon-to-Bone Healing: A Large Animal Study and Short-Term Outcome of a Clinical Trial[J].Adv. Sci, 2024, 2308443. (IF=14.1)

10.Lei Huang , Shihao Zhang , Mengxuan Bian , Xingdong Xiang , Lan Xiao , Jiayi Wang , Shunyi Lu , Weisin Chen , Cheng Zhang , Guokang Mo , Libo Jiang , Yulin Li , Jian Zhang.Injectable, anti-collapse, highly adhesive and plasticity bioactive artificial bone es bone regeneration by moderating oxidative stress in osteoporotic bone defect[J]. Acta Biomaterialia, 2024, 180, 82-103. (IF=9.6)

11.Lei Huang , Peihao Cai , Mengxuan Bian , Jieqin Yu , Lan Xiao , Shunyi Lu , Jiayi Wang , Weisin Chen , Guanjie Han , Xingdong Xiang , Xin Liu , Libo Jiang , Yulin Li , Jian Zhang.Injectable and high-strength PLGA/CPC loaded ALN/MgO bone cement for bone regeneration by facilitating osteogenesis and inhibiting osteoclastogenesis in osteoporotic bone defects[J].Materials Today Bio.2024.26.101092. (IF=10.2)

12.Shengyang Liu, Shicheng He, Can Chen, Chunwang Li, Wei Luo, Jing Wang, Hongyan He, Qiang Chen*, Yulin Li*. A versatile disorder-to-order technology to upgrade polymers into high-performance bioinspired materials. Adv. Healthc. Mater. 2023, 12, 2300068. (IF=9.6)

13.Xiaohuan Yuan, Wei Yang, Yingying Fu, Ziwei Tao, Lan Xiao, Qinzhou Zheng, Dan Wu, Mengya Zhang, Luxin Li, Zhengmao Lu, Yan Wu*, Jie Gao*, Yulin Li*. Four-arm polymer-guided formation of curcumin-loaded flower-like porous microspheres as injectable cell carriers for diabetic wound healing. Adv. Healthc. Mater. 2023, 12, 2301486. (IF=9.6)

14.Yamin Li, Lan Xiao, Daixu Wei, Shengyang Liu, Yin Xiao, Changsheng Liu*, Yulin Li*, Jinzhong Zhao*. Injectable biomimetic hydrogel guided functional bone regeneration by adapting material degradation to tissue healing. Adv. Funct. Mater. 2023, 34, 2213047. (IF=19.0)

15.Yulin Li, Yin Xiao, Changsheng Liu*. The horizon of materiobiology: A perspective on material-guided cell behaviors and tissue engineering. Chem. Rev. 2017, 117, 4376. (IF=55.8)

16.An Chen, Hongwei Lu, Rong Cao, Yi Zhu, Yumeng Li, Renbin Ge, Siruo Zhang, Yulin Li, Lan Xiao, Li Su, Jinhua Zhao*, Honggang Hu*, Zhongling Wang*. A novel MMP-responsive nanoplatform with transformable magnetic resonance property for quantitative tumor bioimaging and synergetic chemo-photothermal therapy[J]. Nano Today, 2022, 45, 101524.(IF=10.9)

17.Qichen Zhang, Wang Ding, Shenglong Ding, Qingbing Meng, Dihan Su, Taiwei Zhang, Qing Chen, Ruixian Lian, Mingdong Zhao, Baqing Yu, Xilei Li*, Yulin Li*, Li-Bo Jiang*. Robust bioactive protein-based screws with dual crosslinked network for internal bone fixation[J]. Composites Part B-Engineering, 2022, 238,109884. (IF=14.2)

18.Zhichao Hu, Jiaqi Lu, Annan Hu, Yongjiang Dou, Sheng Wang, Dihan Su, Wang Ding, Ruixian Lian, Shunyi Lu, Lan Xiao, Yu-Lin Li, Jian Dong, Jian Zhou, Xuyong Yang*, Libo Jiang*. Engineering BPQDs/PLGA nanospheres-integrated wood hydrogel bionic scaffold for combinatory bone repair and osteolytic tumor therapy[J]. Chemical Engineering Journal, 2022, 4, 137269. (IF=13.2)

19.Yamin Li, Can Chen, Jia Jiang, Shengyang Liu, Zeren Zhang, Lan Xiao, Ruixian Lian, Lili Sun, Wei Luo, Michael Tim-yun Ong, Wayne Yuk-wai Lee, Yunsu Chen, Jinzhong Zhao*, Changsheng Liu*, Yulin Li*. Bioactive Film-guided Soft–Hard Interface Design Technology for Multi-tissue Integrative Regeneration, Advanced Science, 2022, 9(15), 2105945. (IF=14.1)

20.Fei Yu, Ruixian Lian, Lu Liu, Ting Liu, Chao Bi, Kan Hong, Shuiquan Zhang, Jiazi Ren, Haikun Wang, Ningjuan Ouyang, Lin-Juan Du, Yuan Liu, Lujun Zhou, Yan Liu, Bing Fang*, Yulin Li*, Sheng-Zhong Duan*, and Lunguo Xia* Biomimetic Hydroxyapatite Nanorods Promote Bone Regeneration via Accelerating Osteogenesis of BMSCs through T Cell-Derived IL-22[J]. ACS Nano, 2022, 16(1), 755-770. (IF=16.0)

21.Fangxue Zhang, Peng Liu, Wang Ding, Qingbing Meng, Dihan Su, Qichen Zhang, Ruixian Lian, Baoqing Yu, Mingdong Zhao, Jian Dong, Yulin Li*, Li-Bo Jiang. Injectable Mussel‐Inspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration. Biomaterials, 2021, 278, 121169 (IF=12.9)

22.Wei Hu, Tingting Xiao, Du Li, Yu Fan, Lingxi Xing*, Xipeng Wang, Yulin Li*, Xiangyang Shi*, Mingwu Shen*. Intelligent Molybdenum Disulfide Complexes as a Platform for Cooperative Imaging-Guided Tri-mode Chemo-Photothermo-Immunotherapy. Advanced Science, 2021,8(14),2100165.(IF=14.1)

23.Kaikai Zheng, Yu Tong, Shihao Zhang, Ruiying He, Lan Xiao, Zoya Iqbal, Yuhong Zhang, Jie Gao*, Lei Zhang, Libo Jiang*, Yulin Li*. Flexible Bicolorimetric Polyacrylamide/Chitosan Hydrogels for Smart Real‐Time Monitoring and Promotion of Wound Healing. Advanced Functional Materials. 2021, 31(34), 2102599. (IF: IF=19.0)

24.Shihao Zhang, Yamin Li, Xiaofeng Qiu, Anqi Jiao, Wei Luo, Xiajie Lin, Xiaohui Zhang, Zeren Zhang, Jiachan Hong, Peihao Cai, Yuhong Zhang, Yan Wu, Jie Gao, Changsheng Liu*, Yulin Li*. Incorporating redox-sensitive nanogels into bioabsorbable nanofibrous membrane to acquire ROS-balance capacity for skin regeneration. Bioactive Materials, 2021, 6, 3461-3472. (IF=20.3)

25.Libo Jiang, Shenglong Ding, Wang Ding, Dihan Su, Fangxue Zhang, Taiwei Zhang, Xiaofan Yin, Lan Xiao, Yulin Li*, Fenglai Yuan, Jian Dong. Injectable Sericin Based Nanocomposite Hydrogel for Multi-modal Imaging-guided Immunomodulatory Bone Regeneration. Chemical Engineering Journal, 2021, 418, 129323.(IF=13.2)

26.Yulin Li, Yin Xiao, Changsheng Liu*. The Horizon of Materiobiology: A Perspective on Material-Guided Cell Behaviors and Tissue Engineering. Chemical Reviews, 2017, 117(5), 4376−4421. (IF=55.8)

27.Panpan Yi, Yifeng Wang, Shihao Zhang, Yuan Zhan, Yuhong Zhang, Zhengguang Sun, Yulin Li,* and Peixin He. Stimulative Nanogels with Enhanced Thermosensitivity for Therapeutic Delivery via β-Cyclodextrin-induced Formation of Inclusion Complexes. Carbohydrate Polymers, 2017, 166, 219-227. (IF=12.5)

28.Guoying Wang, Yaying Chen, Peng Wang, Yifeng Wang, Hua Hong, Yulin Li, Jiangchao Qian, Yuan Yuan, Bo Yu, Changsheng Liu*. Preferential Tumor Accumulation and Desirable Interstitial Penetration of Poly(lactic-co-glycolic acid) Nanoparticles with Dual Coating of Chitosan Oligosaccharide and Polyethylene glycol-poly(D,L-lactic acid). Acta Biomaterialia, 2016, 29, 248–260. (IF=9.6)

29.Yulin Li*, Dina Maciel, João Rodrigues, Xiangyang Shi, Helena Tomás. Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery. Chemical Reviews, 2015, 115(16), 8564-8608. (IF=55.8)

30.Mara Gonçalves, Priscilla Figueira, Dina Maciel, João Rodrigues, Xue Qu, Changsheng Liu, Helena Tomás, Yulin Li*. pH-sensitive Laponite® /doxorubicin/alginate Nanohybrids with Improved Anticancer Efficacy, Acta Biomaterialia, 2014, 10(1), 300-307. (IF: 9.6)

31.Yulin Li*, João Rodrigues and Helena Tomás. Injectable and Biodegradable Hydrogels: Gelation, Biodegradation and Biomedical Applications, Chemical Society Reviews, 2012, 41(6), 2193-2221. (IF: 39)