Recently, the research team led by Professor Liu Runhui from the School of Materials Science and Engineering of our university reported a long-acting glucose-responsive insulin formulation. This insulin formulation has demonstrated excellent properties of long-term glucose-responsive insulin release in a diabetic minipig model, enabling long-term and effective regulation of blood glucose.
The research findings were published in the internationally renowned academic journal Journal of the American Chemical Society (JACS) under the title Poly-(bis(guanidinium)-oxazoline)-Insulin Complex Exerting Long-Acting Glucose-Responsive Insulin Release in Mice and Minipigs.
Figure 1. Design of the glucose-responsive polymer–insulin complex for insulin delivery.
Link:https://doi.org/10.1021/jacs.5c12605
