陈曦    教授、硕/博导

  Professor Xi CHEN

  Email：chenxi@ecust.edu.cn

  所属组室：教育部医用生物材料工程研究中心

  办公地点：徐汇校区新材料大楼1105室

工作经历 Work Experience

    教   授（2025 - 至今）华东理工大学/材料科学与工程学院

    副教授（2019-2025）华东理工大学/材料科学与工程学院

    博士后（2017-2019）美国哈佛大学

    博士后（2016-2017）美国加州大学洛杉矶分校

教育背景 Education

    博士(2016）化学与生物分子工程，墨尔本大学

    硕士(2012）材料科学与工程，清华大学

    学士(2009）材料科学与工程，吉林大学

主要学术/社会兼职 Part-time Job

          中国生物材料学会神经修复材料分会、再生医学材料分会/委员

          国际华人骨研学会/终身会员

          上海市科普志愿者协会“院士专家科学诠释者指导团”/青年科普专家

    招生情况

学生培养 & 招生专业 Student Recruitment

    自2020年以来，指导研究生20余名，所指导学生中多人荣获国家奖学金、PPG奖学金、上海市优秀毕业生及华东理工大学优秀毕业生等荣誉。同时，学生在国际组织工程与再生医学大会、中国生物材料大会等学术交流活动与学科竞赛中表现优异，先后获得优秀口头报告、优秀学生海报等多项奖励。学生毕业后广泛进入中国石化、德国赢创等大型国企及外资企业，保持100%就业率

    招收专业：材料科学与工程（学硕）、生物医学工程（学硕）、材料工程/材料与化工（专硕）（每年招收1名博士生，3-6名硕士生，欢迎对生物材料感兴趣的同学，将个人简历发至邮箱，包括所获奖励、报考分数、成绩单等。To prospective students, please contact chenxi@ecust.edu.cn for more information）

_教学情况

主要教学课程 Teaching

    本科生《生物材料》（上海市重点课程）

    研究生《生物医学工程前沿进展》（华东理工大学课程思政示范课程）

    卓越工程师《生物材料与再生医学工程》（华东理工大学一流研究生课程）

编写教材 Textbook Authorship

    主编《生物材料与再生医学工程》，科学出版社，2026

    参编《Nanobiomaterials（纳米生物材料）》，Chapter 7 Layer-by-Layer Technique, Wiley，2017

科研情况

研究方向 Research Interests——功能生物材料的创制与组织修复再生效应研究

    （1）功能化细胞外基质材料构建及其促神经再生机制研究——中枢神经损伤后的修复与再生，是当前神经科学极具挑战性的前沿课题之一，而构建模拟原生微环境的功能生物材料，已成为推动该领域发展的核心策略。我们的研究聚焦于脊髓损伤、脑外伤等中枢神经损伤疾病，重点设计并制备功能化细胞外基质来源生物材料，通过调控材料拓扑结构、生化信号等性能，协同细胞治疗与康复干预等手段，促进轴突再生与损伤组织的修复，激活再生性或残存性神经环路，最终重建中枢神经系统对肢体及器官的功能性支配

    （2）骨靶向纳米材料构建及对衰老骨修复的作用机制的研究——衰老相关的骨损伤修复，是应对人口老龄化挑战的再生医学领域亟待突破的核心难题之一。本研究聚焦于骨质疏松、老年性骨缺损等衰老相关性骨疾病，系统构建骨靶向纳米材料递送体系，并结合药物干预与微环境调控等多元策略，旨在精准改善衰老骨组织的局部微环境，促进成骨分化与血管新生，激活内源性骨修复潜能，最终实现全身性骨代谢改善与局部骨缺损的有效修复

主要科研项目 Research Funding

    国家自然科学基金委员会, 面上项目，2024.01-2027.12，主持

    国家重点研发计划项目，2022.11-2025.10，子课题负责人

    中央高校基本科研业务费项目，2022.01-2022.12，主持

    国家自然科学基金委员会，青年项目，2022.01-2024.12，主持

    中央高校基本科研业务费项目，2021.01-2021.12，主持

入职华理后的授权专利 Patents@Ecust

3．刘昌胜，陈曦，赵纯俊；2026.03.19；中国；ZL202610335809.2

2．陈曦，刘昌胜，范文文，吴品灼；2026.01.23；中国；ZL2026100933.7

1．刘昌胜，陈曦，王碧雪，张雪薇；2022.04.18；中国；ZL202210405920.6

入职华理后发表的学术论文 Publications@Ecust

23. Jiashang Liu, Chunjun Zhao, Changsheng Liu*, Xi Chen*, Enhancing neural communication via activating calcium-dependent signals toward spinal cord injury repair, Biomaterials 2026, 337, 124541

22. Wenwen Fan, Pinzhuo Wu, Changsheng Liu*, Xi Chen*, Advancedbone-targeted nanomaterials for the systemic treatment of osteoporosis. Regenerative Biomaterials 2026,13, rbag065

21. Zongchang Li, Sixian Zhang, Shu Chen, Qinke Meng, Zhe Lv, Zhilei Niu, Jun Li* , Xi Chen*. In silico discovery and preliminary in vitro evaluation of a SETDB1-related candidate compound associated with early osteogenic effects. Future Pharmacology 2026, 6, 31

20. Shu Chen, Bixue Wang, Qiya Zhang, Changsheng Liu*, Xi Chen*. Neuroprotection and axonal regeneration via ECM-mimetic nanofibers incorporating metal–phenolic network nanoparticles toward spinal cord injury repair. Advanced Science 2026, 13, e13825

19. Sixian Zhang, Yiwei Zeng, Sixu Zhang, Jiajing Zhou*, Changsheng Liu*, Xi Chen*.Metal-phenolic network coated coacervate system mediates mitochondrial modulation and bone homeostasis restoration for postmenopaupal osteoporosis therapy. Nano Letters  2025, 25, 41139388

18. Sixu Zhang, Sixian Zhang, Wenwen Fan, Changsheng Liu, Xi Chen*. Promoting ROS scavenging and osteogenic differentiation by metal–phenolic network nanoparticle-embedded microenvironment-responsive hydrogel for the repair of senile osteoporotic bone defects. Journal of Materials Chemistry B 2025, 13, 10043

17. Yuexin Wang, Shu Chen, Sixian Zhang, Wenwen Fan, Xi Chen*. Cell ratio-dependent osteoblast–endothelial cell crosstalk ing osteogenesis–angiogenesis coupling via regulation of microfluidic perfusion and paracrine signaling. Micromachine 2025, 16, 539

16. Bixue Wang, Qiya Zhang, Changsheng Liu*, Xi Chen*. Counteracting immunodepression by extracellular matrix hydrogel to e brain tissue remodeling and neurological function recovery after traumatic brain injury. Biomaterials 2025, 318, 123181

15. Xi Chen, Yuan Yuan, Yeqiang Tan*, Changsheng Liu*. Strategic study on the development of inorganic non-metallic biomaterials. 无机材料学报 2025, 40, 449

14. Xi Chen*, Weihui Wu, Wei Zhu, Jiajing Zhou, Jingqu Chen, Zhixing Lin, Sixian Zhang, Frank Caruso*, Changsheng Liu*. Regulation of bone remodeling by metal–phenolic networks for the treatment of systemic osteoporosis. ACS Applied Materials & Interfaces 2025, 17, 4, 5995

13. Ruijia Yan, Shu Chen, Bixue Wang, Changsheng Liu, Xi Chen*. Magnetic field-oriented conductive decellularized extracellular matrix hydrogel synergizes with electrical stimulation to e spinal cord injury repair and electrophysiological function restoration. Biomaterials Advances 2025, 169, 214169

12. Zhiqiang Tai, Jiashang Liu, Bixue Wang, Shu Chen, Changsheng Liu, Xi Chen*. The effect of aligned and random electrospun fibers derived from porcine decellularized ECM on mesenchymal stem cell-based treatments for spinal cord injury. Bioengineering 2024, 11, 772 

11. Jiashang Liu, Ruijia Yan, Bixue Wang, Shu Chen, Hua Hong, Changsheng Liu, Xi Chen* Decellularized extracellular matrix enriched with GDNF enhances neurogenesis and remyelination for improved motor recovery after spinal cord injury. Acta Biomaterialia  2024, 180, 308

10. Ying Wang, Fangru Xie, Zirui He, Lingbin Che, Xi Chen*, Yuan Yuan*, Changsheng Liu*. Senescence targeted and NAD dependent SIRT1 activated nanoplatform to counteract stem cell senescence for ing aged bone regeneration. Small 2024, 20, 2304433

9. Zirui He, Chuanhao Sun, Yifan Ma, Xi Chen, Ying Wang, Kai Chen, Fangru Xie, Yan Zhang, Yuan Yuan*, Changsheng Liu*. Rejuvenating aged bone repair through multihierarchy reactive oxygen species-regulated hydrogel. Advanced Materials 2024, 36, 9

8. Ying Wang, Lingbin Che, Xi Chen, Zirui He, Dianwen Song*, Yuan Yuan*, Changsheng Liu*. Repurpose dasatinib and quercetin: Targeting senescent cells ameliorates postmenopausal osteoporosis and rejuvenates bone regeneration. Bioactive Materials 2023,25,13

7. Shuaimin Tang, Dongyong Sha, Zirui He, Xi Chen, Yifan Ma*, Changsheng Liu*, Yuan Yuan*. Environmentally adaptable organo–ionic gel-based electrodes for real-time on-skin electrocardiography monitoring. Advanced Healthcare Materials 2023,12, 2300475

6. Xuewei Zhang, Bixue Wang, Hua Hong, Ying Wang, Jiashang Liu, Changsheng Liu*, Xi Chen*. Decellularized extracellular matrix and mesenchymal stem cells e recovery in traumatic brain injury by synergistically enhancing neurogenesis and attenuating neuroinflammation. Journal of Materials Science & Technology 2023, 138, 17

5. Xiaolong Zhan#, Zhengbo Wen#, Xi Chen*, Qi Lei, Yuxin Chen, Liang Zhou, Guansheng Zheng, Fanhui Kong, Jimin Guo, Yuyou Duan, Yuyan Lai, Panchao Yin, C. Jeffrey Brinker, Honglin Chen*; Wei Zhu*. Polyphenol-mediated biomimetic mineralization of sacrificial metal-organic framework nanoparticles for wound healing. Cell Reports Physical Science 2022, 3, 101103

4. Xi Chen, Shuyan Han, Weihui Wu, Zihan Wu, Yuan Yuan*, Jun Wu*, Changsheng Liu. Harnessing 4D printing bioscaffolds for advanced orthopedics. Small 2022, 18, 2106824

3. Xuewei Zhang, Xi Chen*, Hua Hong, Rubei Hu, Jiashang Liu, ChangshengLiu*. Decellularized extracellular matrix scaffolds: recent trends and emerging strategies in tissue engineering. Bioactive Materials 2022, 10,15 

2. Xi Chen*, Yu Wang, Xuewei Zhang，and Changsheng Liu*. Advances in super-resolution fluorescence microscopy for the study of nano–cell interactions. Biomaterials Science 2021, 9, 5484

1. Xi Chen*, Yu Shrike Zhang, Xinping Zhang, Changsheng Liu*. Organ-on-a-chip platforms for accelerating the evaluation of nanomedicine. Bioactive Materials 2021, 6,1012