报告题目：Centre for Microbial Diseases and Immunity Research University of British Columbia

报告人：加拿大皇家科学院院士Prof. Robert Hancock

报告时间：2018年6月6日（星期三）上午10:00

报告地点：逸夫楼演讲厅

联系人：刘润辉教授

报告人介绍：

Killam Professor, UBC

加拿大皇家科学院院士

Canada Research Chair Holder in Health and Genomics

Associate Faculty Member of the Wellcome Trust Sanger Institute

Honors

1987, Canadian Society of Microbiologists Award

1994, Fellow of the Royal Society of Canada

2000, Jacob Biely Faculty Research Prize, (UBC’s top research award)

2002, Fellow of the American Academy of Microbiology

2005, Fellow of the Infectious Diseases Society of America

2007, Killam Prize (Canada Council’s prize for Health Research)

2009, Order of British Columbia (BC’s highest honour)

2011, Fellow, Canadian Academy of Health Sciences

2012, Prix Galien (Highest Award for Canadian Pharmaceutical

Research and Innovation)

报告内容简介：

The inexorable increase in multidrug resistant infections combined with a decrease in new antibiotic discovery and the lack of compounds to treat recalcitrant infections is creating a potential crisis in human medicine. Thus it is imperative to consider alternatives to conventional antibiotics. Cationic host defense peptides are a key component of innate immunity and have multiple mechanisms that enable them to deal with infections and inflammation including an ability to favourably modulate the innate immune system, and distinct antibiotic and anti-biofilm activities.

It was demonstrated that Cationic host defense peptides(HDPs) boost protective innate immunity while suppressing potentially harmful inflammation/sepsis, and work synergistically with conventional therapies. The manipulation of natural innate immunity represents a new adjunctive therapeutic strategy against antibiotic-resistant infections.The lecture will demonstrate recent progress about a class of peptides based on HDPs that act against biofilms formed by multiple species of bacteria in a manner that is independent of activity vs. planktonic bacteria.