贾瓦哈拉尔尼赫鲁高级科学研究中心(JNCASR) Jayanta Haldar教授应邀来访
发布人: 网站管理员 发布时间: 2017-07-07 作者: 访问次数: 13

        7月3日上午,应材料科学与工程学院刘润辉教授邀请,贾瓦哈拉尔尼赫鲁高级科学研究中心(JNCASR) Jayanta Haldar教授来校访问并作了题为“Engineering Biomaterials and Antibacterials in the Era of Drug Resistance”的精彩学术报告。



        报告中,Haldar教授主要介绍了有望缓解耐药性问题的抗菌药物及相关抗菌材料的最新研究进展。首先,针对细菌耐药性问题,Haldar教授从改性小分子药物这一策略,分别研究了万古霉素修饰物:1. 万古霉素季铵盐中烷烃长度对于抗菌活性及细胞毒性的影响,研究中发现改性后的药物与细胞膜相作用,降低了细菌耐药性问题发生的可能;2. 糖肽修饰的万古霉素也能有效提高抗菌活性,大大降低细胞毒性;3. 四环素修饰的万古霉素在研究中发现能与细菌中的Zn离子络合,继而抗菌活性有效提高了两个数量级。也发现修饰的万古霉素的二聚体能一定地提高抗菌性能。同时,改性的万古霉素不仅对细菌展示了较好的抗菌活性,对于休眠细胞以及生物膜都展示了良好的活性。另一方面,haldar 教授也介绍了其在抗菌材料——涂料、抗菌水凝胶方面的研究,展示了抗菌材料的潜在的应用价值。

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        Jayanta Haldar is an Associate Professor at New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, India. His undergraduate training was at the Presidency College, University of Calcutta and he received his Master of Science and PhD from Indian Institute of Science, Bangalore in 2005. He did Postdoctoral Research from Department of Chemistry, Massachusetts Institute of Technology, USA. His research interests are towards the development of molecular strategies for the prevention  and  treatment  of  infectious  diseases.  He  has  published  many  international  peer-­‐reviewed papers, book chapters and review articles. He has filed various national and international patent applications from 11 different inventions on the development of new drugs and new materials to tackle drug resistance and infections. His research work has been featured in Scientific American, Chemical Engineering News, American Chemical Society, BBC News, TimesofIndia, The Hindu, Rajya Sabha TV, DD India TV etc. He has been awarded as a Ramanujan Fellow from the Department of Science and Technology, Government of India, in 2010. Inventions from his lab received two Biotechnology Industry Research Assistance Council (BIRAC-­‐GYTI) awards in 2015 and 2016 and also received two Gandhian Young Technological Innovation appreciation awards in 2015 and 2016. He is an editorial board member of the journal “Microbial Pathogenesis” of Elsevier and Editorial Advisory Board Members of different journals of American Chemical Society, such as Biomacromolecules and ACS Infectious Diseases. He has been awarded CDRI-­‐Awards 2017 for Excellence in Drug Research.