同济大学杜建忠教授来校访问
发布人: 网站管理员 发布时间: 2017-05-05 作者: 访问次数: 166

        5月4日上午,应材料科学与工程学院刘润辉教授邀请,同济大学杜建忠教授来校访问并作了题为“抗菌和诊疗一体化高分子材料”的精彩学术报告。
        报告中,杜建忠教授系统地介绍了聚合物囊泡在抗菌及诊疗一体化的应用,一方面展示了其课题组构建囊泡的聚合物大分子设计思路,介绍了用于判断(规则/不规则)囊泡厚度的电子束数学模型及囊泡大小及分布的相关实验方法,另一方面也展示了以PTA(聚2-(叔丁基氨基)甲基丙烯酸乙酯)、抗菌肽、拟肽、纳米银离子为体系的四种抗菌囊泡和其在诊疗一体化的应用同时,在抗菌领域,杜建忠教授展示了最近课题组研究的具有优异的抗菌性能的拟肽抗菌囊泡,MIC在2 µg/ml左右,同时细胞毒性较低,在大于1 mg/ml时才显露细胞毒性,兼具成骨和抗菌的双重功能。在诊疗一体化领域,杜建忠教授将Gd装载在囊泡中,从而降低了Gd(钆)的毒性,增加T-1的弛豫时间,提高靶向作用能力,有利于MRI诊疗的灵敏性。最后,杜教授带来其课题组在人工肝糖原囊泡的研究新结果,通过调节多糖和葡萄糖的置换平衡来维持体内葡萄糖的浓度以达到代替胰岛素的功能,延长其治疗效果。从而缓解病人长期皮下注射胰岛素的痛苦。



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        Jianzhong Du received his PhD in chemistry from Institute of Chemistry, Chinese Academy of Sciences (CAS) in 2004 under the supervision of Prof. Yongming Chen. He was also an Alexander von Humboldt Fellow in Germany in 2006. He immediately moved to Prof. Steven Armes group at the University of Sheffield as a postdoctoral fellow in 2004. Then in 2008 he moved to Rachel O’Reilly’s group at the University of Cambridge. He was appointed an ‘Eastern Scholar’ professor in 2009 and a ‘Shanghai 1000 Plan’ professor in 2011 at Tongji University. Currently he is head of department of polymeric materials, Tongji University.
He has published 80 peer-refereed journal papers in J. Am. Chem. Soc., Angew. Chem., ACS Nano, Chem. Soc. Rev., Porg. Polym. Sci., etc. His research interests include polymer vesicles for DNA/RNA/protein delivery, antibacterial, antitumor and theranostic applications. He received the National Award for the Progress in Science and Technology in 2016.