刘润辉
发布人: 发布时间: 2016-09-14 作者: 访问次数: 11380

刘润辉

刘润辉    教授、博导。研究方向:高分子生物材料

国家第十一批“千人计划”青年人才、上海市“东方学者”特聘教授

Email: rliu@ecust.edu.cn      Tel: 021-64253402 

办公室:材料博物馆楼101     邮政地址:上海市梅陇路130号546信箱

 招生专业:材料科学与工程

本课题组招收博士、硕士研究生和博士后

课题组开展交叉领域研究,欢迎对以下某个方向有兴趣的同学加入我们课题组:有机合成、高分子合成、生物、微生物。

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教育及研究经历:


1997-2004   中国   华东理工大学   学士、
硕士
2004-2009   美国   普渡大学(Purdue University)   博士
2009-2010   美国   加州理工学院(California Institute of Technology)   博士后
2010-2014   美国   威斯康星大学麦迪逊校区(University of Wisconsin-Madison)   博士后
2014/12       上海市“东方学者”特聘教授、华东理工大学特聘教授

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主要研究方向:


模拟天然蛋白功能的合成高分子生物材料,包括:
1. 功能化聚合物单体的合成;多功能高分子材料的制备及合成方法研究
2. 生物相容、生物可降解高分子材料的研究与开发
3. 抗细菌、抗真菌生物材料的研制与作用机理研究
4. 具有细胞黏附、细胞选择功能的生物材料研究及在组织修复中的应用
5. 抗非特异性蛋白吸附及微生物生物膜形成的防污材料研究及在生物医学工程领域的应用
6. 蛋白类及小分子药物的体内传输和可控释放研究

              

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代表性学术论文:


15. Liu, R.; Chen, X.; Falk, S.; Masters, K. S.; Weisblum, B.; Gellman, S. H. “Nylon-3 Polymers Active Against Drug-Resistant Candida albicans Biofilms”, J. Am. Chem. Soc. 2015, 137:2183-2186.


14.  Liu, R.; Chen, X.; Falk, S.; Mowery, B.; Karlsson, A.; Weisblum, B.; Palecek, S.; Masters, K. S.; Gellman, S. H. “Structure–Activity Relationships among Antifungal Nylon-3 Polymers:  Identification of Materials Active Against Drug-Resistant Strains of Candida albicans”, J. Am. Chem. Soc. 2014, 136: 4333–4342.                                                 

(Highlighted by SciBX,a publication about translational science that was produce with Nature Publishing Group)

13.  Liu, R.; Chen, X.; Chakraborty, S.; Lemke, J.; Hayouka, Z.; Chow, C.; Welch, R.; Weisblum, B.; Gellman, S. H.; Masters, K. S. “Tuning the Biological Activity Profile of Antibacterial Polymers via Subunit Substitution Pattern”, J. Am. Chem. Soc. 2014, 136: 4410-4418.


12. Liu, R.; Suárez, J. M.; Weisblum, B.; Gellman, S. H.; and McBride, S. M. “Polymers Active Against Clostridium difficile Vegetative Cell Growth and Spore Outgrowth.” J. Am. Chem. Soc. 2014, 136, 14498-14504. (Co-first author)


11. Chakraborty, S.; Liu, R.; Hayouka, Z.; Chen, X.; Ehrhardt, J.; Lu, Q.; Burke, E.; Yang, Y.; Weisblum, B.; Wong, G. C. L.; Masters, K. S; and Gellman, S. H. “Ternary nylon-3 copolymers as host-defense peptide mimics: beyond hydrophobic and cationic subunits.” J. Am. Chem. Soc. 2014, 136, 14530-14535. (Co-first author)


10. Liu, R.; Chen, X.; Gellman, S. H.; Masters, K. S. “Nylon-3 Polymers that Enable Selective Culture of Endothelial Cells”,  J. Am. Chem. Soc. 2013, 135: 16296-16299.


9. Liu, R.; Chen, X.; Hayouka, Z.; Chakraborty, S.; Falk, S. P.; Weisblum, B.; Masters, K. S.; Gellman, S. H. “Nylon-3 Polymers with Selective Antifungal Activity.” J Am Chem Soc. 2013, 135, 5270-5273.
(Featured in JACS Spotlights, J. Am. Chem. Soc. 2013, 135: 5933−5933)


8.  Hayouka, Z.; Chakraborty, S.; Liu, R.; Boersma, M. D.; Weisblum, B.; Gellman, S. H. “Interplay among Subunit Identity, Subunit Proportion, Chain Length, and Stereochemistry in the Activity Profile of Sequence-Random Peptide Mixtures.”     J. Am. Chem. Soc. 2013, 135: 11748-11751.


7.  Liu, R.; Vang, K. Z.; Kreeger, P. K.; Gellman, S. H.; Masters, K. S. “Experimental and Computational Analysis of Cellular Interactions with Nylon-3-Bearing Substrates.” Journal of Biomedical Materials Research Part A. 2012, 100: 2750-2759.
6. Liu, R.; Masters, K. S.; Gellman S. H. “Polymer Chain Length Effects on Fibroblast Attachment on Nylon-3-Modified Surfaces.” Biomacromolecules 2012, 13: 1100-1105.


5.  Liu, R.; Morales-Collazo, O.; Wei, A. “Sulfoform Generation from an Orthogonally Protected Disaccharide.” Carbohydrate Research, 2012, 355: 19-27.


4. Liu, R.; Wei, A. “Solid-Phase Synthesis of 2-Aminoethyl Glucosamine Sulfoforms.” Journal of Carbohydrate Chemistry, 2012, 31: 384-419.


3. Liu, R.; Chanthamontri, C.; Han, H.; Hernández-Torres, J.M.; Wood, K.V.; Mcluckey, S.A.; Wei, A. “Solid-Phase Synthesis of α-Glucosamine Sulfoforms with Fragmentation Analysis by Tandem Mass Spectrometry.” J. Org. Chem. 2008, 73: 6059-6072.       (Featured Article)


2.  Chakraborty, S.; Liu, R.; Lemke, J. J ; Hayouka, Z.; Welch, R. A.; Weisblum, B.; Masters, K. S.; Gellman, S. H. “Effects of Cyclic vs Acyclic Hydrophobic Subunits on the Chemical Structure and Biological Properties of Nylon-3 Copolymers.” ACS Macro Lett. 2013, 2: 753-756.


1. Nadithe, V.; Liu, R.; Killinger, B. A.; Movassaghian S.; Kim, N. H.; Masters, K. S.; Gellman, S. H.; and Merkel, O. M. “Screening Nylon-3 Polymers, a New Class of Cationic Amphiphiles, for siRNA Delivery.”, Mol Pharm. 2014, PMID: 25437915
 

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课题组成员:


朱佶鹏            (博 2013)
陈琦                (硕 2015)
钱宇芯            (硕 2015)
武月铭            (硕 2015)
杨宁宁            (硕 2015)
张丹丰            (硕 2015)
张东辉            (硕 2015)