李玉林
发布人: 李玉林 发布时间: 2019-07-14 作者: 访问次数: 5900


李玉林

姓名

性别

职称

所属教研室

李玉林

副教授

教育部医用生物材料工程研究中心

E-mail

yulinli@ecust.edu.cn

办公室

实验十五楼-724

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主要研究方向:

 

结合化学、材料学和生物学技术,致力于智能纳米微球的药物控释、高强度硬组织修复生物材料的应用研究,包括具有靶向功能的抗肿瘤缓释材料、可降解生物活性材料、活性陶瓷材料的高性能化等。

 

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主要经历与简历:

 

                          1995/9 - 1999/6  湖北大学,化学与材料科学学院,学士
                          1999/9 - 2002/6  湖北大学,化学与材料科学学院,硕士
                          2002/9 - 2005/7  中国科学院,化学研究所,博士
                          2005/9 - 2006/7  法国里尔科技大学,固态结构与性能实验室,访问学者
                          2006/8 - 2008/3  日本国立物质材料研究所,生物材料中心,博士后研究员
                          2008/5 - 2009/7  日本九州大学,应用化学系,Global-COE博士后研究员
                          2009/7 - 2014/5  葡萄牙马德拉大学,化学与物质研究中心,研究助理教授
                          2014/6 –  至今  华东理工大学,材料科学与工程学院,副教授

                          2016/5–2016/8   美国罗格斯大学,新泽西生物材料研究中心,访问学者 

兼职与荣誉

    

  • 5/2019   委员     中国研究型医院协会运动医学分会

  • 8/2019   三等奖   2019年中国生物材料大会产业化论坛暨第一届中国生物材料学会创新创业大赛三等奖”,2019822-25日,大连,中国

  • 9/2007   Best Oral Presentation Award, The 7th Asian BioCeramics Symposium 2007 (ABC 2007)(Oral Presentation), September 25-28, 2007, Osaka, Japan.







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近期代表性论文


  1. Wei Luo, Xin Xu, Bingjie Zhou, Peixin He, Yulin Li*, Changsheng Liu*. Formation of enzymatic/redox-switching nanogates on mesoporous silica nanoparticles for anticancer drug delivery. Mater. Sci. Eng., C, 2019, https://doi.org/10.1016/j.msec.2019.03.028. (Impact factor(IF):5.080)

  2. Jianming Wu, Xi Cheng, YulinLi, Guisheng Yang. Constructing biodegradable nanochitin-contained chitosan hydrogel beads for fast and efficient removal of Cu(II) from aqueous solution. Carbohydrate Polymers, 2019, 211, 152-160. (IF:5.158)

  3. Ling Zheng, Bingjie Zhoua, Xiaofeng Qiu, Xin Xu, Gang Li, Wayne YW Lee*, Jia Jiang and Yulin Li*. Direct Assembly of Anticancer Drugs to Form Laponite-based Nanocomplexes for Therapeutic Co-Delivery. Mater. Sci. Eng., C, 2019, https://doi.org/10.1016/j.msec.2019.02.083. (IF:5.080)

  4. Peng Xie, Jiahui Du, Yulin Li*, Jingyao Wu, Hongyan He, Xinquan Jiang, Changsheng Liu*. Robust Hierarchical Porous MBG Scaffolds with Promoted Biomineralization Ability. Colloids and Surfaces B: Biointerfaces, 2019, https://doi.org/10.1016/j.colsurfb.2019.02.042 (IF:3.997)

  5. Mingji Su, Yong Liu, Shihong Li, Zhengping Fang, Benqiao He, Yuhong Zhang, Yulin Li, Peixin He. A rubber-like, underwater superoleophobic hydrogel for efficient oil/water separation. Chemical Engineering Journal, 2019, 361, 364-372. (IF:6.735)

  6. Doudou Gao, Lanlan Duan, Meng Wu, Xianxun Wang, Zhengguang Sun, Yuhong Zhang, Yulin Li, Peixin He. Preparation of thermo/redox/pHstimulative poly(NisopropylacrylamidecoN,N’dimethylaminoethyl methacrylate) nanogels and their DOX release behaviors. Journal of Biomedical Materials Research A, 2019, https://doi.org/10.1002/jbm.a.36611. (IF:3.231)

  7. Jiahui Du, Peng Xie, Shuxian Lin, Yuqiong Wu, Deliang Zeng, Yulin Li*, Xinquan Jiang*. Time-Phase Sequential Utilization of Adipose-Derived Mesenchymal Stem Cells on Mesoporous Bioactive Glass for Restoration of Critical Size Bone Defects. ACS Appl. Mater. Interfaces, 2018, 10, 28340–28350. (IF: 8.097)

  8. Xin Xu, Jine Wang, Yifeng Wang, Liming Zhao, Yulin Li, Changsheng Liu. Formation of graphene oxide-hybridized nanogels for combinative anticancer therapy. Nanomedicine: Nanotechnology, Biology and Medicine, 2018, 14(7), 2387-2395.(IF:6.500)

  9. Xin Xu, Xiaofeng Wang, Wei Luo, Qihong Qian, Qian Li, Baosan Han, Yulin Li*. Triple cell-responsive nanogels for delivery of drug into cancer cells. Colloids and Surfaces B: Biointerfaces, 2018, 163, 362-368. (IF:3.997)

  10. Bingjie Zhou, Bozhen Wu, Jine Wang, Qihong Qian, Jing Wang, Hongbin Xu, Sun Yang, Pan Feng, Wu Chen, Yulin Li*, Jia Jiang*, and Baosan Han. Drug-Mediation Formation of Nanohybrids for Sequential Therapeutic Delivery in Cancer Cells. Colloids and Surfaces B: Biointerfaces, 2018, 163, 284–290. (IF:3.997)

  11. Yang Yang, Xiaofeng Qiu, Yi Sun, Yifeng Wang, Jine Wang, Yulin Li* and Changsheng Liu*. Development of Bioabsorbable Polylactide Membrane with Controllable Hydrophilicity for Adjustment of Cell Behaviors. Royal Society Open Science, 2018, 5, 170868. (IF:2.504)

  12. Ping Ji, Bingjie Zhou, Yuan Zhan, Yifeng Wang, Yuhong Zhang, Yulin Li, and Peixin He. Multi-stimulative nanogels with enhanced thermosensitivity for intracellular therapeutic delivery. ACS Appl. Mater. Interfaces. 2017, 9 (45), 39143–39151. (IF: 8.097)

  13. Yulin Li and Changsheng Liu*. Nanomaterials-based Bone Regeneration. Nanoscale, 2017, 9(15), 4862-4874. (IF:7.233)

  14. Panpan Yi, Yifeng Wang,Shihao Zhang, Yuan Zhan,Yuhong Zhang, Zhengguang Sun, Yulin Li,*and Peixin He. Stimulative Nanogels with Enhanced Thermosensitivity for Therapeutic Delivery via β-Cyclodextrin-induced Formation of Inclusion Complexes. Carbohydrate Polymers, 2017, 166, 219-227. (IF:5.158).

  15. Yulin Li, Yin Xiao, Changsheng Liu*. The Horizon of Materiobiology: A Perspective on Material-Guided Cell Behaviors and Tissue Engineering. Chemical Reviews, 2017,117(5), 4376−4421. (IF: 54.301)

  16. Panpan Yi, Yifeng Wang, Peixin He, Yuan Zhan, Zhengguang Sun, Yulin Li* and Yuhong Zhang. Study on β-Cyclodextrin-Complexed Nanogels with Improved Thermal Response for Anticancer Drug Delivery. Mater. Sci. Eng., C, 2017, 78, 773-779. (IF:5.080)

  17. Yifeng Wang, Jine Wang, Yi Sun, Yang Yang, Yuan Yuan, Yulin Li* and Changsheng Liu*. In Situ Biodegradable Crosslinking of Cationic Oligomer Coating on Mesoporous Silica Nanoparticles for Drug Delivery. Colloids and Surfaces B: Biointerfaces, 2017, 153, 272–279. (IF:3.997)

  18. Lanlan Duan, Yifeng Wang, Yuhong Zhang*, Zhiguo Wang, Yulin Li*, Peixin He. pH/redox/thermo- Stimulative Nanogels with Enhanced Thermosensitivity via Incorporation of Cationic and Anionic Components for Anticancer Drug Delivery. International Journal of Polymeric Materials and Polymeric Biomaterials. 2017, 67(5), 288-296. (IF:2.127)

  19. Yifeng Wang;Yi Sun; Jine Wang;Yang Yang; Yulin Li*; Yuan Yuan; Changsheng Liu*. Charge-Reversal APTES-modified Mesoporous Silica Nanoparticles with High Drug Loading and Release Controllability. ACS Appl Mater Interfaces, 2016, 8(27), 17166-17175.(IF: 8.097)

  20. Guoying Wang, Yaying Chen, Peng Wang, Yifeng Wang, Hua Hong, Yulin Li, Jiangchao Qian, Yuan Yuan, Bo Yu, Changsheng Liu*. Preferential Tumor Accumulation and Desirable Interstitial Penetration of Poly(lactic-co-glycolic acid) Nanoparticles with Dual Coating of Chitosan Oligosaccharide and Polyethylene glycol-poly(D,L-lactic acid). Acta Biomaterialia, 2016, 29(1), 248–260. (IF:6.383)

  21. Yulin Li*, Dina Maciel, João Rodrigues, Xiangyang Shi, Helena Tomás. Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery. Chemical Reviews, 2015, 115(16), 8564-8608.(IF: 54.301)

  22. Kai Yang, Jing Zhang, Xiaoyu Ma, Yifan Ma, Chao Kan, Haiyan Ma, Yulin Li*, Yuan Yuan*, and Changsheng Liu*. β-Tricalcium Phospate/Poly(polyol sebacate) Scaffolds with Robust Mechanical Property for Bone Tissue Engineering. Mater. Sci. Eng., C, 2015, 56C, 37-47. (IF:5.080)

  23. Yuan Zhan, Mara Gonçalves, Panpan Yi, Débora Capelo, Yuhong Zhang, João Rodrigues, Changsheng Liu, Helena Tomás, Yulin Li*, Peixin He. Thermo/redox/pH- Triple Sensitive Poly(N-isopropylacrylamide-co-acrylic acid) Nanogels for Anticancer Drug Delivery, J. Mater. Chem. B, 2015, 3, 4221-4230. (IF:4.776)

  24. Guoying Wang, Dina Maciel, Yilun Wu, João Rodrigues, Xiangyang Shi, Yuan Yuan, Changsheng Liu, Helena Tomás, Yulin Li*. Amphiphilic Polymer-Mediated Formation of Laponite®-Based Nanohybrids with Robust Stability and pH Sensitivity for Anticancer Drug Delivery, ACS Appl. Mater. Inter., 2014, 6(19), 16687–16695. (IF: 8.097)

  25. Mara Gonçalves, Dina Maciel, Débora Capêlo,Shili Xiao, Wenjie Sun, João Rodrigues, Xiangyang Shi, Helena Tomás, Yulin Li*. Dendrimer-Assisted Formation of Fluorescent Nanogels for Drug Delivery and Intracellular Imaging, Biomacromolecules, 2014,15(2), 492–499. (IF: 5.738)

  26. Mara Gonçalves, Priscilla Figueira, Dina Maciel, João Rodrigues, Xue Qu, Changsheng Liu, Helena Tomás, Yulin Li*. pH-sensitive Laponite®/doxorubicin/alginate Nanohybrids with Improved Anticancer Efficacy, Acta Biomaterialia, 2014, 10(1), 300-307. (IF: 6.383)

  27. Mara Gonçalves, Priscilla Figueira, Dina Maciel, João Rodrigues, Xiangyang Shi, Helena Tomás, Yulin Li*. Antitumor Efficacy of Doxorubicin-Loaded Laponite/Alginate Hybrid Hydrogels. Macromolecular Bioscience, 2014, 14(1), 110-120. (IF: 3.412)

  28. Dina Maciel, Priscilla Figueira, Shili Xiao, Xiangyang Shi, Helena Tomás, Yulin Li*. Redox-responsive Alginate Nanogels with Enhanced Anticancer Cytotoxicity. Biomacromolecules, 2013, 14(9), 3140–3146. (IF: 5.738)

  29. Yulin Li*, João Rodrigues and Helena Tomás. Injectable and Biodegradable Hydrogels: Gelation, Biodegradation and Biomedical Applications, Chem. Soc. Rev., 2012, 41(6), 2193-2221. (IF:40.182)


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承担/参与项目名称(角色/资助金额/资助期限)

来源

生物可吸收高分子基纳米活性材料及植入器械制备技术/主持/274万元/2019-2023


非细胞型活性仿生支架促进老年骨损伤修复应用研究/主持/62万元/2020-2023


生物基耐高温聚酰胺的关键技术及产业化/主持/160万元/2019-2020


兼具干细胞募集能力和成骨诱导功能的微纳结构活性材料的构建及快速成骨机制研究/主持/60万元/2018-2021


高品质聚乳酸纤维及其纺织品规模化制备与应用/主持/80万元/2017-2021


兼具成血管能力的水凝胶联合基因工程化内源性脂肪干细胞治疗脊髓损伤研究/主持/40万元/2018-2021



仿生骨多级结构活性支架材料的构建及促进骨组织快速修复的研究/主持/16万元/2017-2021


强度可控的多级微纳结构活性支架材料与生长因子协同促进骨组织快速修复的研究/主持/30万元/2015-2018



基于3D打印技术构建高强度活性支架材料与生长因子协同骨修复研究/主持/10万元/2015-2018


基于微纳结构的高弹高强复合活性骨修复材料的研究/主持/10万元/2015-2018


Self-assembled Nanoparticles based on PEG-PLA-dendrimer building blocks for dual gene/drug delivery(主持 / 15.7万欧 / 2012-2015

Development of Novel Dendrimer-Based Nanoparticles for Dual Mode Computed Tomography and Magnetic Resonance Imaging of Tumors(参与/19.8万欧/2013-2015







































































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